Clinical features and prognostic factors of angioimmunoblastic T-cell lymphoma in Taiwan: A single-institution experience

Han Nan Lin, Chun Yu Liu, Ying Chung Hong, Jih Tung Pai, Ching Fen Yang, Yuan Bin Yu, Liang Tsai Hsiao, Tzeon Jye Chiou, Jin Hwang Liu, Jyh Pyng Gau, Cheng Hwai Tzeng, Po Min Chen

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13 引文 斯高帕斯(Scopus)

摘要

Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma that carries a poor prognosis. This study retrospectively analyzed patients with AITL from a single institution in Taiwan, aiming to define the clinical features and prognostic factors. Patients with AITL treated at our institution from February 1988 through January 2010 were enrolled. Factors associated with overall survival (OS) were determined by statistical methods. A total of 31 Taiwanese patients (21 males) were identified. The median age was 74 years (range, 27-90). Among all patients, 67.7% were Ann Arbor stage III or IV, 58.1% presented with B symptoms, 48.4% had hypoalbuminenia (<35 g/L), and 63.3% had elevated lactate dehydrogenase (LDH) at diagnosis. First-line chemotherapy was mostly CHOP (cyclophosphamide, vincristine, doxorubicin, and prednisolone)-based and complete response (CR) was achieved in 25% of patients. The actuarial 2-year survival rate was 38.7%, and the median OS was 14.9 months. In multivariate analysis, initial presentation with fever (p = 0.035), advanced stage (p = 0.024), and failure to achieve CR (p = 0.029) were independent adverse factors associated with poorer OS. Interestingly, OS did not differ whether chemotherapy regimens contained anthracycline or not. Taiwanese patients with AITL were usually elderly. Despite the prognosis being generally poor, patients with AITL should be treated with the goal of achieving CR, regardless of anthracycline- or non-anthracycline-based chemotherapy.

原文英語
頁(從 - 到)2208-2214
頁數7
期刊Leukemia and Lymphoma
51
發行號12
DOIs
出版狀態已發佈 - 十二月 2010
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科
  • 癌症研究

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