Clinical characteristics and treatment outcome in a Taiwanese population of patients with Epstein-Barr virus-positive diffuse large B-cell lymphoma

Chang Hsien Lu, Kam Fai Lee, Chih Cheng Chen, Yi Yang Chen, Cih En Huang, Pei Shan Tsai, Hsing Yi Tsou, Hui Ju Chou, Miao Fen Chen, Pin Tsung Chen, Kuan Der Lee, Jrhau Lung

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Objective: Epstein-Barr virus-positive diffuse large B-cell lymphoma is a provisional entity in the 2008 World Health Organization classification of tumors of hematopoietic and lymphoid tissues. Reports on the characteristics and clinical outcome of this disease in different geographic regions showed great disparities. Methods: To define the clinical characteristics as well as the prognostic impact of Epstein-Barr virus infection on diffuse large B-cell lymphoma in Taiwan, we retrospectively investigated the Epstein-Barr virus status of 89 patients with newly diagnosed diffuse large B-cell lymphoma in our institute. Results: Using a cutoff point of positive nuclear staining of Epstein-Barr virus-encoded RNA-1-in situ hybridization in ≥20% of the examined cells, we identified 15 cases (16.9%) of the entire study cohort as Epstein-Barr virus-positive diffuse large B-cell lymphoma. The clinical and laboratory features were not different between Epstein-Barr virus-positive and -negative diffuse large B-cell lymphoma patients. Univariate analysis showed patients with diffuse large B-cell lymphoma that were either Epstein-Barr virus-positive or had activated B-cell-like features had an inferior overall survival. Older age, advanced stage and lymphoma with activated B-cell-like features or Epstein-Barr virus-encoded RNA positivity were independent prognostic factors affecting overall survival on multivariate analysis. Patients with two or three of these adverse-risk factors were considered high risk and fared far worse than patients with no or only one adverse factor. Conclusions: Taken together, we demonstrated that a higher frequency of Epstein-Barr virus association was detected in a Taiwanese cohort of diffuse large B-cell lymphoma patients, and Epstein-Barr virus-encoded RNA positivity was shown to add important prognostic value in these patients.
原文英語
頁(從 - 到)1164-1171
頁數8
期刊Japanese Journal of Clinical Oncology
44
發行號12
DOIs
出版狀態已發佈 - 十二月 1 2014
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Lu, C. H., Lee, K. F., Chen, C. C., Chen, Y. Y., Huang, C. E., Tsai, P. S., Tsou, H. Y., Chou, H. J., Chen, M. F., Chen, P. T., Lee, K. D., & Lung, J. (2014). Clinical characteristics and treatment outcome in a Taiwanese population of patients with Epstein-Barr virus-positive diffuse large B-cell lymphoma. Japanese Journal of Clinical Oncology, 44(12), 1164-1171. https://doi.org/10.1093/jjco/hyu155