Clinical and Prognostic Association of Transcription Factor SOX4 in Gastric Cancer

Chia Lang Fang, You Cheng Hseu, Yi Feng Lin, Shih Ting Hung, Chein Tai, Yih Huei Uen, Kai Yuan Lin

研究成果: 雜誌貢獻文章同行評審

37 引文 斯高帕斯(Scopus)


Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process by which this disease develops and progresses. This study investigated correlations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised gastric tissues from 168 patients with GC. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P

期刊PLoS One
出版狀態已發佈 - 12月 20 2012

ASJC Scopus subject areas

  • 農業與生物科學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 醫藥 (全部)


深入研究「Clinical and Prognostic Association of Transcription Factor SOX4 in Gastric Cancer」主題。共同形成了獨特的指紋。