Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia

Han-Sun Chiang, Shauh Der Yeh, Chien Chih Wu, Boo Chung Huang, Hui Ju Tsai, Chia Lang Fang

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion: The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.
原文英語
頁(從 - 到)369-375
頁數7
期刊Asian Journal of Andrology
6
發行號4
出版狀態已發佈 - 十二月 2004

    指紋

ASJC Scopus subject areas

  • Nephrology
  • Endocrinology

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