Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan

Wen Chen Li, Shin Ru Shih, Yhu Chering Huang, Guang Wu Chen, Shih Cheng Chang, Mei Jen Hsiao, Kuo Chien Tsao, Tzou Yien Lin

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

Background: Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak.
原文英語
頁(從 - 到)45-51
頁數7
期刊Journal of Clinical Virology
42
發行號1
DOIs
出版狀態已發佈 - 五月 2008
對外發佈Yes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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