Cisd2 mediates mitochondrial integrity and life span in mammals

Yi Fan Chen, Cheng Heng Kao, Ralph Kirby, Ting Fen Tsai

研究成果: 雜誌貢獻回顧型文獻同行評審

48 引文 斯高帕斯(Scopus)

摘要

CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.
原文英語
頁(從 - 到)1043-1045
頁數3
期刊Autophagy
5
發行號7
DOIs
出版狀態已發佈 - 10月 1 2009
對外發佈

ASJC Scopus subject areas

  • 細胞生物學
  • 分子生物學

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