Circulation of donor lymphocytes after blood transfusion in man

G. P. Schechter, J. Whang Peng, W. McFarland

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)

摘要

Atypical lymphocytes (ATL) appear in the circulation of a large proportion of patients during the first week following a blood transfusion. In order to determine the source of these ATL, cytogenetic studies were performed on the peripheral blood leukocytes of ten adult patients who received fresh blood from donors of the opposite sex. Nine of the ten patients had spontaneously dividing mononuclear cells of the recipient or host karyotype circulating during the latter part of the first week after transfusion. In two patients, the spontaneously dividing cells were of donor as well as of host origin. Six patients had circulating phytohemagglutinin-responsive lymphocytes of the donor karyotype noted from 1-7 days after transfusion. These findings lend support to our hypothesis that the increase in circulating atypical lymphocytes seen 1 wk after transfusion represents the counterpart in vivo of the in vitro mixed leukocyte reaction. The dividing donor cells may represent a subclinical graft-versus-host reaction.
原文英語
頁(從 - 到)651-656
頁數6
期刊Blood
49
發行號4
出版狀態已發佈 - 十二月 1 1977
對外發佈Yes

ASJC Scopus subject areas

  • Hematology

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