Circulating tissue inhibitor of matrix metalloproteinase-1 is associated with aldosterone-induced diastolic dysfunction

Chi Sheng Hung, Chia Hung Chou, Xue Ming Wu, Yi Yao Chang, Vin Cent Wu, Ying Hsien Chen, Yuan Shian Chang, Yao Chou Tsai, Ming Jai Su, Yi Lwun Ho, Ming Fong Chen, Kwan Dun Wu, Yen Hung Lin

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Objective: To test if collagen markers are associated with aldosterone-induced diastolic dysfunction. Background: Although primary aldosteronism is associated with more prominent cardiac remodeling and diastolic dysfunction, the reversibility of diastolic function is unclear. In addition, there is no known biomarker associated with aldosterone-induced diastolic dysfunction. Methods: We enrolled 27 patients with aldosteroneproducing adenoma (APA) preparing for adrenalectomy, and 27 patients with essential hypertension prospectively from October 2006 to March 2010 at a tertiary referral center. Plasma matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) were measured, and echocardiography including tissue Doppler images was performed in both groups and 1 year after receiving adrenalectomy in the APA group. Results: The baseline plasma TIMP-1 level (88.4±38.7 vs. 63.6±32.5 ng/ml; P=0.014), left ventricular mass index (LVMI), and E/E' ratio (11.5±2.9 vs. 9.0±2.1; P<0.001) were significantly higher in the APA group. The baseline plasma TIMP-1 level significantly correlated with the E/E' ratio, LVMI, interventricular septum, and left atrial diameter. The plasma MMP-2 level did not correlate with the left ventricular structure parameters, except for interventricular septum thickness. After adrenalectomy, LVMI and E/E' ratio improved significantly. The postadrenalectomy plasma TIMP-1 levels, but not MMP-2 levels, also decreased. The change of plasma TIMP-1 levels was negatively associated with the postadrenalectomy E/E' ratio after adjustment for age, sex, BMI, and mean blood pressure (β-coefficient=-3.6, P=0.004). Conclusion: Excess of aldosterone induces cardiac diastolic dysfunction, which is reversible by adrenalectomy. TIMP-1 is associated with the aldosterone-induced diastolic dysfunction.

原文英語
頁(從 - 到)1922-1930
頁數9
期刊Journal of Hypertension
33
發行號9
DOIs
出版狀態已發佈 - 2015
對外發佈

ASJC Scopus subject areas

  • 內科學
  • 生理學
  • 心臟病學與心血管醫學

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