Circadian variation of tacrolimus disposition in liver allograft recipients

David I. Min, Hsiang Yin Chen, Alfredo Fabrega, Ferdinand O. Ukah, You Min Wu, Claudia Corwin, M. Kay Ashton, Maureen Martin

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to characterize the circadian variation of oral tacrolimus disposition in 8 stable liver allograft recipients. In the steady state, a total of 23 blood samples was taken before and after tacrolimus administration during a 24-hr period and the pharmacokinetic parameters were compared. The area under the curve (AUC) of tacrolimus after the morning dose was significantly larger than after the evening dose (211±43 ng · hr/ml [morning] vs. 179±45 ng · hr/ml [evening], P=0.02). The time to peak (Tmax) was significantly shorter after the morning dose than after the evening dose (1.6±0.7 hr [morning] vs. 2.9±0.6 hr [evening], P=0.002). The peak (Cmax) was significantly higher after the morning dose than after the evening dose (32.2±10.2 ng/ml [morning] vs. 19.1±4.3 ng/ml [evening], P=0.003). However, the trough (Cmin) was not significantly different between the morning dose and the evening dose (13.1±3.9 ng/ml [morning] vs. 13.3±4.4 ng/ml [evening], P=0.4). This study demonstrated that tacrolimus disposition in liver transplant patients was determined by administration time.

原文英語
頁(從 - 到)1190-1192
頁數3
期刊Transplantation
62
發行號8
DOIs
出版狀態已發佈 - 十月 27 1996
對外發佈Yes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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