Circadian rhythm in the Ca2+-inhibitable adenylyl cyclase activity of the rat striatum

Yijuang Chern, Eminy H Y Lee, Hsing Lin Lai, Hai Long Wang, Yi Chao Lee, Yung Hao Ching

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

原文英語
頁(從 - 到)205-208
頁數4
期刊FEBS Letters
385
發行號3
DOIs
出版狀態已發佈 - 五月 6 1996
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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