Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)


Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

頁(從 - 到)499-505
期刊Biochemical and Biophysical Research Communications
出版狀態已發佈 - 九月 15 1983

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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