Objective: Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear. Materials and methods: Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models. Results: A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33%) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95% confidence interval 1.03–2.36, P,0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95% confidence interval 1.03–1.39; P,0.05). Conclusion: Longer periods of treatment may be required for TB patients who are current smokers.
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Safety Research
- Chemical Health and Safety
Chuang, H. C., Su, C. L., Liu, H. C., Feng, P. H., Lee, K. Y., Chuang, K. J., Lee, C-N., & Bien, M. Y. (2015). Cigarette smoke is a risk factor for severity and treatment outcome in patients with culture-positive tuberculosis. Therapeutics and Clinical Risk Management, 11, 1539-1544. . https://doi.org/10.2147/TCRM.S87218