摘要

Objective: Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear. Materials and methods: Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models. Results: A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33%) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95% confidence interval 1.03–2.36, P,0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95% confidence interval 1.03–1.39; P,0.05). Conclusion: Longer periods of treatment may be required for TB patients who are current smokers.
原文英語
文章編號168
頁(從 - 到)1539-1544
頁數6
期刊Therapeutics and Clinical Risk Management
11
DOIs
出版狀態已發佈 - 十月 6 2015

指紋

Pulmonary diseases
Smoke
Tobacco Products
contagious disease
Hazards
Tuberculosis
Logistics
X rays
smoking
Smoking
Sputum
Lung Diseases
confidence
Confidence Intervals
Disease
regression
reporting system
grading
Proportional Hazards Models
Thorax

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Safety Research
  • Chemical Health and Safety

引用此文

@article{840ffc68b2474aff87dde0c750d93c8d,
title = "Cigarette smoke is a risk factor for severity and treatment outcome in patients with culture-positive tuberculosis",
abstract = "Objective: Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear. Materials and methods: Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models. Results: A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33{\%}) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95{\%} confidence interval 1.03–2.36, P,0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95{\%} confidence interval 1.03–1.39; P,0.05). Conclusion: Longer periods of treatment may be required for TB patients who are current smokers.",
keywords = "Chest X-ray, Cigarette, Immunity, Mycobacterium tuberculosis",
author = "Chuang, {Hsiao Chi} and Su, {Chien Ling} and Liu, {Hui Chiao} and Feng, {Po Hao} and Lee, {Kang Yun} and Chuang, {Kai Jen} and Chun-Nin Lee and Bien, {Mauo Ying}",
year = "2015",
month = "10",
day = "6",
doi = "10.2147/TCRM.S87218",
language = "English",
volume = "11",
pages = "1539--1544",
journal = "Therapeutics and Clinical Risk Management",
issn = "1176-6336",
publisher = "Dove Medical Press Ltd.",

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T1 - Cigarette smoke is a risk factor for severity and treatment outcome in patients with culture-positive tuberculosis

AU - Chuang, Hsiao Chi

AU - Su, Chien Ling

AU - Liu, Hui Chiao

AU - Feng, Po Hao

AU - Lee, Kang Yun

AU - Chuang, Kai Jen

AU - Lee, Chun-Nin

AU - Bien, Mauo Ying

PY - 2015/10/6

Y1 - 2015/10/6

N2 - Objective: Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear. Materials and methods: Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models. Results: A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33%) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95% confidence interval 1.03–2.36, P,0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95% confidence interval 1.03–1.39; P,0.05). Conclusion: Longer periods of treatment may be required for TB patients who are current smokers.

AB - Objective: Smoking has been associated with tuberculosis (TB); however, the effects of smoking on the effectiveness of TB treatment remain unclear. Materials and methods: Data were retrieved from case notes and interviews of subjects registered in the TB-reporting system from 2010 to 2012. Study cases were defined as subjects with TB-positive sputum cultures, whereas the controls were defined as subjects with non-TB-related pulmonary diseases. Statistical analyses included logistic regression and multivariate Cox proportional hazard regression models. Results: A total of 245 cases with cultures positive for TB and 114 controls with non-TB-related pulmonary diseases and negative sputum cultures were recruited. Current smokers had the highest failure rate (33%) for TB treatment, and they had the most severe pulmonary lesions based on chest X-ray grading. Current smokers had a 1.36-fold (95% confidence interval 1.03–2.36, P,0.05) higher odds ratio for cultures positive for TB compared with nonsmokers. In subjects with TB-positive cultures, current smoking was associated with an increase in treatment days required for cultures to convert from positive to negative (hazard ratio 1.12, 95% confidence interval 1.03–1.39; P,0.05). Conclusion: Longer periods of treatment may be required for TB patients who are current smokers.

KW - Chest X-ray

KW - Cigarette

KW - Immunity

KW - Mycobacterium tuberculosis

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