摘要
| 原文 | 英語 |
|---|---|
| 頁數 | 1 |
| 期刊 | Particle and Fibre Toxicology |
| 卷 | 15 |
| 發行號 | 1 |
| DOIs | |
| 出版狀態 | 已發佈 - 十一月 9 2018 |
指紋
Keywords
- Air pollution
- Inflammation
- Memory deficiency
- Neurotoxicity
- Oxidative stress
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
引用此文
Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats. / Shih, Chi Hsiang; Chen, Jen Kun; Kuo, Li Wei; Cho, Kuan Hung; Hsiao, Ta Chih; Lin, Zhe Wei; Lin, Yi Syuan; Kang, Jiunn Horng; Lo, Yu Chun; Chuang, Kai Jen; Cheng, Tsun Jen; Chuang, Hsiao Chi.
於: Particle and Fibre Toxicology, 卷 15, 編號 1, 09.11.2018.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats
AU - Shih, Chi Hsiang
AU - Chen, Jen Kun
AU - Kuo, Li Wei
AU - Cho, Kuan Hung
AU - Hsiao, Ta Chih
AU - Lin, Zhe Wei
AU - Lin, Yi Syuan
AU - Kang, Jiunn Horng
AU - Lo, Yu Chun
AU - Chuang, Kai Jen
AU - Cheng, Tsun Jen
AU - Chuang, Hsiao Chi
PY - 2018/11/9
Y1 - 2018/11/9
N2 - BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.
AB - BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.
KW - Air pollution
KW - Inflammation
KW - Memonry deficiency
KW - Neurotoxicity
KW - Oxidative stress
KW - Air pollution
KW - Inflammation
KW - Memory deficiency
KW - Neurotoxicity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85056419573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056419573&partnerID=8YFLogxK
U2 - 10.1186/s12989-018-0281-1
DO - 10.1186/s12989-018-0281-1
M3 - Article
C2 - 30413208
AN - SCOPUS:85056419573
VL - 15
JO - Particle and Fibre Toxicology
JF - Particle and Fibre Toxicology
SN - 1743-8977
IS - 1
ER -