Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

Chi Hsiang Shih, Jen Kun Chen, Li Wei Kuo, Kuan Hung Cho, Ta Chih Hsiao, Zhe Wei Lin, Yi Syuan Lin, Jiunn Horng Kang, Yu Chun Lo, Kai Jen Chuang, Tsun Jen Cheng, Hsiao Chi Chuang

研究成果: 雜誌貢獻 › 文章

摘要

BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.
原文英語
頁數1
期刊Particle and Fibre Toxicology
卷15
發行號1
DOIs
出版狀態已發佈 - 十一月 9 2018

指紋

Particulate Matter
Rats
Brain
Hippocampus
Air Pollution
Lung
Air pollution
Brain Waves
Cerebellum
Olfactory Bulb
Air
Brain Edema
Object recognition
Entropy
Short-Term Memory
Interleukin-4
Magnetic resonance imaging
Frequency bands
Sprague Dawley Rats
Interleukin-6

Keywords

  • Air pollution
  • Inflammation
  • Memory deficiency
  • Neurotoxicity
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

引用此文

Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats. / Shih, Chi Hsiang; Chen, Jen Kun; Kuo, Li Wei; Cho, Kuan Hung; Hsiao, Ta Chih; Lin, Zhe Wei; Lin, Yi Syuan; Kang, Jiunn Horng; Lo, Yu Chun; Chuang, Kai Jen; Cheng, Tsun Jen; Chuang, Hsiao Chi.

於: Particle and Fibre Toxicology, 卷 15, 編號 1, 09.11.2018.

研究成果: 雜誌貢獻 › 文章

Shih, CH, Chen, JK, Kuo, LW, Cho, KH, Hsiao, TC, Lin, ZW, Lin, YS, Kang, JH, Lo, YC, Chuang, KJ, Cheng, TJ & Chuang, HC 2018, 'Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats', Particle and Fibre Toxicology, 卷 15, 編號 1. https://doi.org/10.1186/s12989-018-0281-1
Shih CH, Chen JK, Kuo LW, Cho KH, Hsiao TC, Lin ZW 等. Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats. Particle and Fibre Toxicology. 2018 11月 9;15(1). https://doi.org/10.1186/s12989-018-0281-1
Shih, Chi Hsiang ; Chen, Jen Kun ; Kuo, Li Wei ; Cho, Kuan Hung ; Hsiao, Ta Chih ; Lin, Zhe Wei ; Lin, Yi Syuan ; Kang, Jiunn Horng ; Lo, Yu Chun ; Chuang, Kai Jen ; Cheng, Tsun Jen ; Chuang, Hsiao Chi. / Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats. 於: Particle and Fibre Toxicology. 2018 ; 卷 15, 編號 1.
@article{8098aa0928394374ac472c18273a0167,
title = "Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats",
abstract = "BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.",
keywords = "Air pollution, Inflammation, Memonry deficiency, Neurotoxicity, Oxidative stress, Air pollution, Inflammation, Memory deficiency, Neurotoxicity, Oxidative stress",
author = "Shih, {Chi Hsiang} and Chen, {Jen Kun} and Kuo, {Li Wei} and Cho, {Kuan Hung} and Hsiao, {Ta Chih} and Lin, {Zhe Wei} and Lin, {Yi Syuan} and Kang, {Jiunn Horng} and Lo, {Yu Chun} and Chuang, {Kai Jen} and Cheng, {Tsun Jen} and Chuang, {Hsiao Chi}",
year = "2018",
month = "11",
day = "9",
doi = "10.1186/s12989-018-0281-1",
language = "English",
volume = "15",
journal = "Particle and Fibre Toxicology",
issn = "1743-8977",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

AU - Shih, Chi Hsiang

AU - Chen, Jen Kun

AU - Kuo, Li Wei

AU - Cho, Kuan Hung

AU - Hsiao, Ta Chih

AU - Lin, Zhe Wei

AU - Lin, Yi Syuan

AU - Kang, Jiunn Horng

AU - Lo, Yu Chun

AU - Chuang, Kai Jen

AU - Cheng, Tsun Jen

AU - Chuang, Hsiao Chi

PY - 2018/11/9

Y1 - 2018/11/9

N2 - BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.

AB - BACKGROUND: Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM1), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cortex, cerebellum, and hippocampus), olfactory bulb, and serum after 3 and 6 months of whole-body exposure in 6-month-old Sprague Dawley rats. RESULTS: The rats were exposed to 16.3 ± 8.2 (4.7~ 68.8) μg/m3 of PM1 during the study period. An MRI analysis showed that whole-brain and hippocampal volumes increased with 3 and 6 months of PM1 exposure. A short-term memory deficiency occurred with 3 months of exposure to PM1 as determined by a novel object recognition (NOR) task, but there were no significant changes in motor functions. There were no changes in frequency bands or multiscale entropy of brainwaves. Exposure to 3 months of PM1 increased 8-isoporstance in the cortex, cerebellum, and hippocampus as well as hippocampal inflammation (interleukin (IL)-6), but not in the olfactory bulb. Systemic CCL11 (at 3 and 6 months) and IL-4 (at 6 months) increased after PM1 exposure. Light chain 3 (LC3) expression increased in the hippocampus after 6 months of exposure. Spongiosis and neuronal shrinkage were observed in the cortex, cerebellum, and hippocampus (neuronal shrinkage) after exposure to air pollution. Additionally, microabscesses were observed in the cortex after 6 months of PM1 exposure. CONCLUSIONS: Our study first observed cerebral edema and brain impairment in adult rats after chronic exposure to traffic-related air pollution.

KW - Air pollution

KW - Inflammation

KW - Memonry deficiency

KW - Neurotoxicity

KW - Oxidative stress

KW - Air pollution

KW - Inflammation

KW - Memory deficiency

KW - Neurotoxicity

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85056419573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056419573&partnerID=8YFLogxK

U2 - 10.1186/s12989-018-0281-1

DO - 10.1186/s12989-018-0281-1

M3 - Article

VL - 15

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

SN - 1743-8977

IS - 1

ER -

存取文件