摘要

Epidemiological evidence has shown that air pollution is associated with chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effects of air pollution on patients with COPD and pneumonia. A case-control study of patients who had undergone thoracentesis for pleural effusion drainage in a hospital was recruited for this study. COPD and non-COPD patients with pneumonia respectively served as the case and control groups. Increases in particulate matter of <2.5 μm in aerodynamic diameter (PM 2.5 ) and NO 2 increased the risk of pneumonia in COPD patients (adjusted odd ratio (OR) = 4.136, 95% confidence interval (CI) = 1.740–9.832 for PM 2.5 ; adjusted OR = 1.841, 95% CI = 1.117–3.036 for NO 2 ). COPD patients with pneumonia had higher levels of CD14 in pleural effusion than did non-COPD with pneumonia (p < 0.05). An increase in CD14 of the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.126, 95% CI = 1.009–1.256). We further observed that an increase in Cu and a decrease in Zn in the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.005, 95% CI = 1.000–1.010 for Cu; adjusted OR = 0.988, 95% CI = 0.978–0.997 for Zn). In conclusion, our results suggest that COPD patients had a high risk of pneumonia occurring due to air pollution exposure.
原文英語
頁(從 - 到)524-529
頁數6
期刊Science of the Total Environment
677
DOIs
出版狀態已發佈 - 八月 10 2019

指紋

Pulmonary diseases
pneumonia
Air pollution
atmospheric pollution
confidence interval
pulmonary disease
pollution exposure
Particulate Matter
Drainage
aerodynamics
particulate matter
Aerodynamics
drainage

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

引用此文

@article{be30051fece443d2bf5a8d73d89b63a1,
title = "Chronic obstructive pulmonary disease patients have a higher risk of occurrence of pneumonia by air pollution",
abstract = "Epidemiological evidence has shown that air pollution is associated with chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effects of air pollution on patients with COPD and pneumonia. A case-control study of patients who had undergone thoracentesis for pleural effusion drainage in a hospital was recruited for this study. COPD and non-COPD patients with pneumonia respectively served as the case and control groups. Increases in particulate matter of <2.5 μm in aerodynamic diameter (PM 2.5 ) and NO 2 increased the risk of pneumonia in COPD patients (adjusted odd ratio (OR) = 4.136, 95{\%} confidence interval (CI) = 1.740–9.832 for PM 2.5 ; adjusted OR = 1.841, 95{\%} CI = 1.117–3.036 for NO 2 ). COPD patients with pneumonia had higher levels of CD14 in pleural effusion than did non-COPD with pneumonia (p < 0.05). An increase in CD14 of the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.126, 95{\%} CI = 1.009–1.256). We further observed that an increase in Cu and a decrease in Zn in the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.005, 95{\%} CI = 1.000–1.010 for Cu; adjusted OR = 0.988, 95{\%} CI = 0.978–0.997 for Zn). In conclusion, our results suggest that COPD patients had a high risk of pneumonia occurring due to air pollution exposure.",
keywords = "COPD, Immunity, Metal, Particulate matter, Pleural effusion, Pneumonia",
author = "Shu-Chuan Ho and Kai-Jen Chuang and Kang-Yun Lee and Jen-Kun Chen and Sheng-Ming Wu and Tzu-Tao Chen and Chun-Nin Lee and Chih-Cheng Chang and Po-Hao Feng and Kuan-Yuan Chen and Chein-Ling Su and Cheng-Yu Tsai and Hsiao-Chi Chuang",
year = "2019",
month = "8",
day = "10",
doi = "10.1016/j.scitotenv.2019.04.358",
language = "English",
volume = "677",
pages = "524--529",
journal = "Science of the Total Environment",
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TY - JOUR

T1 - Chronic obstructive pulmonary disease patients have a higher risk of occurrence of pneumonia by air pollution

AU - Ho, Shu-Chuan

AU - Chuang, Kai-Jen

AU - Lee, Kang-Yun

AU - Chen, Jen-Kun

AU - Wu, Sheng-Ming

AU - Chen, Tzu-Tao

AU - Lee, Chun-Nin

AU - Chang, Chih-Cheng

AU - Feng, Po-Hao

AU - Chen, Kuan-Yuan

AU - Su, Chein-Ling

AU - Tsai, Cheng-Yu

AU - Chuang, Hsiao-Chi

PY - 2019/8/10

Y1 - 2019/8/10

N2 - Epidemiological evidence has shown that air pollution is associated with chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effects of air pollution on patients with COPD and pneumonia. A case-control study of patients who had undergone thoracentesis for pleural effusion drainage in a hospital was recruited for this study. COPD and non-COPD patients with pneumonia respectively served as the case and control groups. Increases in particulate matter of <2.5 μm in aerodynamic diameter (PM 2.5 ) and NO 2 increased the risk of pneumonia in COPD patients (adjusted odd ratio (OR) = 4.136, 95% confidence interval (CI) = 1.740–9.832 for PM 2.5 ; adjusted OR = 1.841, 95% CI = 1.117–3.036 for NO 2 ). COPD patients with pneumonia had higher levels of CD14 in pleural effusion than did non-COPD with pneumonia (p < 0.05). An increase in CD14 of the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.126, 95% CI = 1.009–1.256). We further observed that an increase in Cu and a decrease in Zn in the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.005, 95% CI = 1.000–1.010 for Cu; adjusted OR = 0.988, 95% CI = 0.978–0.997 for Zn). In conclusion, our results suggest that COPD patients had a high risk of pneumonia occurring due to air pollution exposure.

AB - Epidemiological evidence has shown that air pollution is associated with chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effects of air pollution on patients with COPD and pneumonia. A case-control study of patients who had undergone thoracentesis for pleural effusion drainage in a hospital was recruited for this study. COPD and non-COPD patients with pneumonia respectively served as the case and control groups. Increases in particulate matter of <2.5 μm in aerodynamic diameter (PM 2.5 ) and NO 2 increased the risk of pneumonia in COPD patients (adjusted odd ratio (OR) = 4.136, 95% confidence interval (CI) = 1.740–9.832 for PM 2.5 ; adjusted OR = 1.841, 95% CI = 1.117–3.036 for NO 2 ). COPD patients with pneumonia had higher levels of CD14 in pleural effusion than did non-COPD with pneumonia (p < 0.05). An increase in CD14 of the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.126, 95% CI = 1.009–1.256). We further observed that an increase in Cu and a decrease in Zn in the pleural effusion increased the risk of pneumonia in COPD patients (adjusted OR = 1.005, 95% CI = 1.000–1.010 for Cu; adjusted OR = 0.988, 95% CI = 0.978–0.997 for Zn). In conclusion, our results suggest that COPD patients had a high risk of pneumonia occurring due to air pollution exposure.

KW - COPD

KW - Immunity

KW - Metal

KW - Particulate matter

KW - Pleural effusion

KW - Pneumonia

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U2 - 10.1016/j.scitotenv.2019.04.358

DO - 10.1016/j.scitotenv.2019.04.358

M3 - Article

VL - 677

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EP - 529

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

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