Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk

Kuang Wei Huang, Yi-Chun Kuan, Nai-Fang Chi, Yao Hsien Huang, Jiing Chyuan Luo, Li-Nien Chien

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Background: The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. Methods: Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002-2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible. Cox proportional hazard regression was used to evaluate the risk of recurrent PUB during the follow-up period. Results: The cumulative recurrence rate of PUB was significantly higher in the patients with COPD than in the non-COPD matched controls (2. years: 10.8% vs 9.3%; 6. years: 18.3% vs 15.7%, . P all <. 0.05), with an adjusted hazard ratio (HR) of 1.17 (95% confidence interval [CI], 1.08-1.26, . P . <. 0.001) and 1.19 (95% CI, 1.12-1.26, . P . <. 0.001) within 2-year and 6-year follow-ups, respectively. Patients with COPD using steroids were at a marginally higher risk of recurrent PUB than those who did not use steroids. Multivariate stratified analysis revealed similar results in many subgroups. Conclusions: The risk of recurrent PUB is higher in patients with COPD than in patients without COPD.
原文英語
頁(從 - 到)75-82
期刊European Journal of Internal Medicine
37
DOIs
出版狀態已發佈 - 一月 1 2017

指紋

Peptic Ulcer
Chronic Obstructive Pulmonary Disease
Hemorrhage
Obstructive Lung Diseases
Steroids
Confidence Intervals
Propensity Score
National Health Programs
Taiwan
Multivariate Analysis
Demography
Databases
Recurrence
Research

ASJC Scopus subject areas

  • Internal Medicine

引用此文

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title = "Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk",
abstract = "Background: The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. Methods: Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002-2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible. Cox proportional hazard regression was used to evaluate the risk of recurrent PUB during the follow-up period. Results: The cumulative recurrence rate of PUB was significantly higher in the patients with COPD than in the non-COPD matched controls (2. years: 10.8{\%} vs 9.3{\%}; 6. years: 18.3{\%} vs 15.7{\%}, . P all <. 0.05), with an adjusted hazard ratio (HR) of 1.17 (95{\%} confidence interval [CI], 1.08-1.26, . P . <. 0.001) and 1.19 (95{\%} CI, 1.12-1.26, . P . <. 0.001) within 2-year and 6-year follow-ups, respectively. Patients with COPD using steroids were at a marginally higher risk of recurrent PUB than those who did not use steroids. Multivariate stratified analysis revealed similar results in many subgroups. Conclusions: The risk of recurrent PUB is higher in patients with COPD than in patients without COPD.",
keywords = "Chronic obstructive pulmonary disease (COPD), Recurrent peptic ulcer bleeding (PUB), Steroids",
author = "Huang, {Kuang Wei} and Yi-Chun Kuan and Nai-Fang Chi and Huang, {Yao Hsien} and Luo, {Jiing Chyuan} and Li-Nien Chien",
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AU - Huang, Kuang Wei

AU - Kuan, Yi-Chun

AU - Chi, Nai-Fang

AU - Huang, Yao Hsien

AU - Luo, Jiing Chyuan

AU - Chien, Li-Nien

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. Methods: Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002-2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible. Cox proportional hazard regression was used to evaluate the risk of recurrent PUB during the follow-up period. Results: The cumulative recurrence rate of PUB was significantly higher in the patients with COPD than in the non-COPD matched controls (2. years: 10.8% vs 9.3%; 6. years: 18.3% vs 15.7%, . P all <. 0.05), with an adjusted hazard ratio (HR) of 1.17 (95% confidence interval [CI], 1.08-1.26, . P . <. 0.001) and 1.19 (95% CI, 1.12-1.26, . P . <. 0.001) within 2-year and 6-year follow-ups, respectively. Patients with COPD using steroids were at a marginally higher risk of recurrent PUB than those who did not use steroids. Multivariate stratified analysis revealed similar results in many subgroups. Conclusions: The risk of recurrent PUB is higher in patients with COPD than in patients without COPD.

AB - Background: The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. Methods: Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002-2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible. Cox proportional hazard regression was used to evaluate the risk of recurrent PUB during the follow-up period. Results: The cumulative recurrence rate of PUB was significantly higher in the patients with COPD than in the non-COPD matched controls (2. years: 10.8% vs 9.3%; 6. years: 18.3% vs 15.7%, . P all <. 0.05), with an adjusted hazard ratio (HR) of 1.17 (95% confidence interval [CI], 1.08-1.26, . P . <. 0.001) and 1.19 (95% CI, 1.12-1.26, . P . <. 0.001) within 2-year and 6-year follow-ups, respectively. Patients with COPD using steroids were at a marginally higher risk of recurrent PUB than those who did not use steroids. Multivariate stratified analysis revealed similar results in many subgroups. Conclusions: The risk of recurrent PUB is higher in patients with COPD than in patients without COPD.

KW - Chronic obstructive pulmonary disease (COPD)

KW - Recurrent peptic ulcer bleeding (PUB)

KW - Steroids

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