摘要
Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.
| 原文 | 英語 |
|---|---|
| 文章編號 | 2385 |
| 期刊 | International Journal of Molecular Sciences |
| 卷 | 19 |
| 發行號 | 8 |
| DOIs | |
| 出版狀態 | 已發佈 - 八月 13 2018 |
指紋
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
引用此文
Chronic niche inflammation in endometriosis-associated infertility : Current understanding and future therapeutic strategies. / Lin, Yi Heng; Chen, Ya Hsin; Chang, Heng Yu; Au, Heng Kien; Tzeng, Chii Ruey; Huang, Yen Hua.
於: International Journal of Molecular Sciences, 卷 19, 編號 8, 2385, 13.08.2018.研究成果: 雜誌貢獻 › 回顧型文獻
}
TY - JOUR
T1 - Chronic niche inflammation in endometriosis-associated infertility
T2 - Current understanding and future therapeutic strategies
AU - Lin, Yi Heng
AU - Chen, Ya Hsin
AU - Chang, Heng Yu
AU - Au, Heng Kien
AU - Tzeng, Chii Ruey
AU - Huang, Yen Hua
PY - 2018/8/13
Y1 - 2018/8/13
N2 - Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.
AB - Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.
KW - Endometriosis
KW - Immunomodulation
KW - Infertility
KW - Inflammation
KW - Mesenchymal stem cell
KW - Niche
UR - http://www.scopus.com/inward/record.url?scp=85052149543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052149543&partnerID=8YFLogxK
U2 - 10.3390/ijms19082385
DO - 10.3390/ijms19082385
M3 - Review article
AN - SCOPUS:85052149543
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 8
M1 - 2385
ER -