Chronic hepatitis infection is associated with extrahepatic cancer development: A nationwide population-based study in Taiwan

Abram Bunya Kamiza, Fu Hsiung Su, Wen Chang Wang, Fung Chang Sung, Shih Ni Chang, Chih Ching Yeh

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. Methods: Patients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) for determining the association between CHI and cancer development. Results: The patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 % CI: 1.09-1.70), liver cancer (HR: 21.47, 95 % CI: 18.0-25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 % CI: 1.07-3.91), pancreatic cancer (HR: 2.61, 95 % CI: 1.47-4.61), kidney cancer (HR: 1.72, 95 % CI: 1.10-2.68), ovarian cancer (HR: 2.31, 95 % CI: 1.21-4.39), and non-Hodgkin's lymphoma (HR: 2.10, 95 % CI: 1.25-3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 % CI: 20.9-30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 % CI: 1.42-4.73), ovarian cancer (HR: 5.15, 95 % CI: 1.98-13.4), and non-Hodgkin's lymphoma (HR: 2.30, 95 % CI: 1.34-3.96). Conclusion: The present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.
原文英語
文章編號861
期刊BMC Cancer
16
發行號1
DOIs
出版狀態已發佈 - 十一月 8 2016

指紋

Chronic Hepatitis
Taiwan
Confidence Intervals
Infection
Population
Neoplasms
Virus Diseases
Liver Neoplasms
Hepatitis B virus
Hepacivirus
Bile Duct Neoplasms
Extrahepatic Bile Ducts
Gallbladder
Ovarian Neoplasms
Non-Hodgkin's Lymphoma
Kidney Neoplasms
National Health Programs
Pancreatic Neoplasms
Proportional Hazards Models
Longitudinal Studies

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

引用此文

Chronic hepatitis infection is associated with extrahepatic cancer development : A nationwide population-based study in Taiwan. / Kamiza, Abram Bunya; Su, Fu Hsiung; Wang, Wen Chang; Sung, Fung Chang; Chang, Shih Ni; Yeh, Chih Ching.

於: BMC Cancer, 卷 16, 編號 1, 861, 08.11.2016.

研究成果: 雜誌貢獻文章

@article{85391e10e57a45a380726c480a16bf59,
title = "Chronic hepatitis infection is associated with extrahepatic cancer development: A nationwide population-based study in Taiwan",
abstract = "Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. Methods: Patients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 {\%} confidence intervals (CIs) for determining the association between CHI and cancer development. Results: The patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 {\%} CI: 1.09-1.70), liver cancer (HR: 21.47, 95 {\%} CI: 18.0-25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 {\%} CI: 1.07-3.91), pancreatic cancer (HR: 2.61, 95 {\%} CI: 1.47-4.61), kidney cancer (HR: 1.72, 95 {\%} CI: 1.10-2.68), ovarian cancer (HR: 2.31, 95 {\%} CI: 1.21-4.39), and non-Hodgkin's lymphoma (HR: 2.10, 95 {\%} CI: 1.25-3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 {\%} CI: 20.9-30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 {\%} CI: 1.42-4.73), ovarian cancer (HR: 5.15, 95 {\%} CI: 1.98-13.4), and non-Hodgkin's lymphoma (HR: 2.30, 95 {\%} CI: 1.34-3.96). Conclusion: The present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.",
keywords = "Cancer risk, Hepatitis B virus, Hepatitis C virus, Taiwan",
author = "Kamiza, {Abram Bunya} and Su, {Fu Hsiung} and Wang, {Wen Chang} and Sung, {Fung Chang} and Chang, {Shih Ni} and Yeh, {Chih Ching}",
year = "2016",
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language = "English",
volume = "16",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",
number = "1",

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TY - JOUR

T1 - Chronic hepatitis infection is associated with extrahepatic cancer development

T2 - A nationwide population-based study in Taiwan

AU - Kamiza, Abram Bunya

AU - Su, Fu Hsiung

AU - Wang, Wen Chang

AU - Sung, Fung Chang

AU - Chang, Shih Ni

AU - Yeh, Chih Ching

PY - 2016/11/8

Y1 - 2016/11/8

N2 - Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. Methods: Patients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) for determining the association between CHI and cancer development. Results: The patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 % CI: 1.09-1.70), liver cancer (HR: 21.47, 95 % CI: 18.0-25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 % CI: 1.07-3.91), pancreatic cancer (HR: 2.61, 95 % CI: 1.47-4.61), kidney cancer (HR: 1.72, 95 % CI: 1.10-2.68), ovarian cancer (HR: 2.31, 95 % CI: 1.21-4.39), and non-Hodgkin's lymphoma (HR: 2.10, 95 % CI: 1.25-3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 % CI: 20.9-30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 % CI: 1.42-4.73), ovarian cancer (HR: 5.15, 95 % CI: 1.98-13.4), and non-Hodgkin's lymphoma (HR: 2.30, 95 % CI: 1.34-3.96). Conclusion: The present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.

AB - Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. Methods: Patients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) for determining the association between CHI and cancer development. Results: The patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 % CI: 1.09-1.70), liver cancer (HR: 21.47, 95 % CI: 18.0-25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 % CI: 1.07-3.91), pancreatic cancer (HR: 2.61, 95 % CI: 1.47-4.61), kidney cancer (HR: 1.72, 95 % CI: 1.10-2.68), ovarian cancer (HR: 2.31, 95 % CI: 1.21-4.39), and non-Hodgkin's lymphoma (HR: 2.10, 95 % CI: 1.25-3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 % CI: 20.9-30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 % CI: 1.42-4.73), ovarian cancer (HR: 5.15, 95 % CI: 1.98-13.4), and non-Hodgkin's lymphoma (HR: 2.30, 95 % CI: 1.34-3.96). Conclusion: The present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.

KW - Cancer risk

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Taiwan

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