Chronic granulocytic leukemia without the Philadelphia chromosome

G. P. Canellos, J. Whang Peng, V. T. DeVita

研究成果: 雜誌貢獻文章同行評審

39 引文 斯高帕斯(Scopus)

摘要

Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted since 1961. Twenty patients lacked the Ph1 chromosome. All were previously untreated. When compared with Ph1 positive patients, CGL patients with Ph1 negative disease had a higher median age (60 compared with 42 yr) and were diagnosed at lower median leukocyte (75,000) and platelets counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 mth compared with 44 mth for the Ph1 positive group. Four patients survived more than 5 yr and 2, more than 10 yr. Thirty five per cent of the Ph1 negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.
原文英語
頁(從 - 到)467-470
頁數4
期刊American Journal of Clinical Pathology
65
發行號4
DOIs
出版狀態已發佈 - 一月 1 1976
對外發佈Yes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

指紋 深入研究「Chronic granulocytic leukemia without the Philadelphia chromosome」主題。共同形成了獨特的指紋。

引用此