Chronic granulocytic leukemia without the Philadelphia chromosome

G. P. Canellos, J. Whang Peng, V. T. DeVita

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted since 1961. Twenty patients lacked the Ph1 chromosome. All were previously untreated. When compared with Ph1 positive patients, CGL patients with Ph1 negative disease had a higher median age (60 compared with 42 yr) and were diagnosed at lower median leukocyte (75,000) and platelets counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 mth compared with 44 mth for the Ph1 positive group. Four patients survived more than 5 yr and 2, more than 10 yr. Thirty five per cent of the Ph1 negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.
原文英語
頁(從 - 到)467-470
頁數4
期刊American Journal of Clinical Pathology
65
發行號4
DOIs
出版狀態已發佈 - 一月 1 1976
對外發佈Yes

指紋

Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aneuploidy
Platelet Count
Leukocyte Count
Cytogenetics
Bone Marrow
Drug Therapy
Cell Line
Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

引用此文

Chronic granulocytic leukemia without the Philadelphia chromosome. / Canellos, G. P.; Whang Peng, J.; DeVita, V. T.

於: American Journal of Clinical Pathology, 卷 65, 編號 4, 01.01.1976, p. 467-470.

研究成果: 雜誌貢獻文章

Canellos, G. P. ; Whang Peng, J. ; DeVita, V. T. / Chronic granulocytic leukemia without the Philadelphia chromosome. 於: American Journal of Clinical Pathology. 1976 ; 卷 65, 編號 4. 頁 467-470.
@article{98f22cb730d84844b4a96bf21ba94048,
title = "Chronic granulocytic leukemia without the Philadelphia chromosome",
abstract = "Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted since 1961. Twenty patients lacked the Ph1 chromosome. All were previously untreated. When compared with Ph1 positive patients, CGL patients with Ph1 negative disease had a higher median age (60 compared with 42 yr) and were diagnosed at lower median leukocyte (75,000) and platelets counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 mth compared with 44 mth for the Ph1 positive group. Four patients survived more than 5 yr and 2, more than 10 yr. Thirty five per cent of the Ph1 negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.",
author = "Canellos, {G. P.} and {Whang Peng}, J. and DeVita, {V. T.}",
year = "1976",
month = "1",
day = "1",
doi = "10.1093/ajcp/65.4.467",
language = "English",
volume = "65",
pages = "467--470",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "4",

}

TY - JOUR

T1 - Chronic granulocytic leukemia without the Philadelphia chromosome

AU - Canellos, G. P.

AU - Whang Peng, J.

AU - DeVita, V. T.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted since 1961. Twenty patients lacked the Ph1 chromosome. All were previously untreated. When compared with Ph1 positive patients, CGL patients with Ph1 negative disease had a higher median age (60 compared with 42 yr) and were diagnosed at lower median leukocyte (75,000) and platelets counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 mth compared with 44 mth for the Ph1 positive group. Four patients survived more than 5 yr and 2, more than 10 yr. Thirty five per cent of the Ph1 negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.

AB - Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted since 1961. Twenty patients lacked the Ph1 chromosome. All were previously untreated. When compared with Ph1 positive patients, CGL patients with Ph1 negative disease had a higher median age (60 compared with 42 yr) and were diagnosed at lower median leukocyte (75,000) and platelets counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 mth compared with 44 mth for the Ph1 positive group. Four patients survived more than 5 yr and 2, more than 10 yr. Thirty five per cent of the Ph1 negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.

UR - http://www.scopus.com/inward/record.url?scp=0017279639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017279639&partnerID=8YFLogxK

U2 - 10.1093/ajcp/65.4.467

DO - 10.1093/ajcp/65.4.467

M3 - Article

C2 - 1063540

AN - SCOPUS:0017279639

VL - 65

SP - 467

EP - 470

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 4

ER -