Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats

M. Hsiung Yen, J. Hua Yang, J. Rong Sheu, Y. Mei Lee, Y. An Ding

研究成果: 雜誌貢獻文章

52 引文 斯高帕斯(Scopus)

摘要

This study investigated the effect of physical training on endothelial function in spontaneously hypertensive rats (SHR). After 3 months, in conscious trained- and untrained-SHR body weight, systolic blood pressure and heart rate were 220 ± 6 g vs. 271 ± 9 g, 172 ± 7 mmHg vs. 210 ± 8 mmHg and 314 ± 10 vs. 348 ± 12 beats/min, respectively. In vitro, the dose-response curves of norepinephrine in isolated intact aortic and mesenteric rings from the exercise trained-SHR were significantly lower than those from the untrained-SHR. With denuded preparations, norepinephrine concentration-response curves were shifted to the left both in the trained- and untrained-SHR. This shift in the trained-SHR exceeded that in the untrained-SHR. The vasodilator response to acetylcholine in the trained-SHR was significantly greater than that in the untrained-SHR. Either Nω-nitro-L-arginine (100 μmol/l) or methylene blue (10 μmol/l) inhibited acetylcholine-induced vasodilator effect in aorta of trained- and untrained-SHR, but not in mesenteric artery of trained-SHR. Tetraethylammonium (10 mmol/l) inhibited significantly the Nω-nitro-L-arginine and methylene blue-resistant relaxation in mesenteric artery of trained-SHR,but not by indomethacin (10 μmol/l). Collectively, these data demonstrate that chronic exercise increases EDRF/EDHF production (presumably by increasing endothelial shear stress), and may contribute to the enhanced effects of post-exercise hypotension.1.

原文英語
頁(從 - 到)2205-2213
頁數9
期刊Life Sciences
57
發行號24
DOIs
出版狀態已發佈 - 十一月 3 1995
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

指紋 深入研究「Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats」主題。共同形成了獨特的指紋。

  • 引用此