Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats

M. Hsiung Yen, J. Hua Yang, J. Rong Sheu, Y. Mei Lee, Y. An Ding

研究成果: 雜誌貢獻文章

52 引文 (Scopus)

摘要

This study investigated the effect of physical training on endothelial function in spontaneously hypertensive rats (SHR). After 3 months, in conscious trained- and untrained-SHR body weight, systolic blood pressure and heart rate were 220 ± 6 g vs. 271 ± 9 g, 172 ± 7 mmHg vs. 210 ± 8 mmHg and 314 ± 10 vs. 348 ± 12 beats/min, respectively. In vitro, the dose-response curves of norepinephrine in isolated intact aortic and mesenteric rings from the exercise trained-SHR were significantly lower than those from the untrained-SHR. With denuded preparations, norepinephrine concentration-response curves were shifted to the left both in the trained- and untrained-SHR. This shift in the trained-SHR exceeded that in the untrained-SHR. The vasodilator response to acetylcholine in the trained-SHR was significantly greater than that in the untrained-SHR. Either Nω-nitro-L-arginine (100 μmol/l) or methylene blue (10 μmol/l) inhibited acetylcholine-induced vasodilator effect in aorta of trained- and untrained-SHR, but not in mesenteric artery of trained-SHR. Tetraethylammonium (10 mmol/l) inhibited significantly the Nω-nitro-L-arginine and methylene blue-resistant relaxation in mesenteric artery of trained-SHR,but not by indomethacin (10 μmol/l). Collectively, these data demonstrate that chronic exercise increases EDRF/EDHF production (presumably by increasing endothelial shear stress), and may contribute to the enhanced effects of post-exercise hypotension.1.

原文英語
頁(從 - 到)2205-2213
頁數9
期刊Life Sciences
57
發行號24
DOIs
出版狀態已發佈 - 十一月 3 1995
對外發佈Yes

指紋

Inbred SHR Rats
Endothelium
Rats
Dilatation
Methylene Blue
Mesenteric Arteries
Vasodilator Agents
Acetylcholine
Arginine
Norepinephrine
Blood Pressure
Tetraethylammonium
Blood pressure
Indomethacin
Aorta
Shear stress
Heart Rate
Body Weight

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

引用此文

Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats. / Yen, M. Hsiung; Yang, J. Hua; Sheu, J. Rong; Lee, Y. Mei; Ding, Y. An.

於: Life Sciences, 卷 57, 編號 24, 03.11.1995, p. 2205-2213.

研究成果: 雜誌貢獻文章

Yen, M. Hsiung ; Yang, J. Hua ; Sheu, J. Rong ; Lee, Y. Mei ; Ding, Y. An. / Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats. 於: Life Sciences. 1995 ; 卷 57, 編號 24. 頁 2205-2213.
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