Chromophore-modified antitumor anthracenes. 1. Cytotoxic activity of 9-acyloxy 1,5-dichloroanthracene analogues

H. S. Huang, J. M. Hwang, Y. M. Jen, C. W. Tao, K. Y. Lee, C. H. Shi

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)


As part of our program aimed at exploring the effect of introducing side chains to the anthracenone chromophore, we synthesized a novel series of 9-acyloxy 1,5-dichloroanthracene derivatives. Reduction of 1,5-dichloro anthraquinone with stannous chloride in boiling HCl and acetic acid with concomitant selective acylation led to the corresponding 9-acyloxy 1,5-dichloroanthracenes. These compounds were evaluated in vitro for their ability to inhibit the growth of human oral epidermoid carcinoma (KB) cells, human cervical carcinoma (GBM8401) cells and Chinese hamster ovary (CHO) cells, respectively. Compounds 3g, 3j and 3k were more potent against GBM cells than doxorubicin. Compounds 3j and 3v were more potent against KB cells than doxorubicin. Although compound 3j was active against both GBM and KB cells which was not cytotoxic to CHO cells. The implications of 9-acyloxy-1,5-dichloroanthracene analogs as potential anticancer agents are discussed.
頁(從 - 到)71-83
期刊Chinese Pharmaceutical Journal
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • 生物工程
  • 藥學科學


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