Chromatography in plasma fractionation: benefits and future trends

研究成果: 雜誌貢獻回顧型文獻

79 引文 (Scopus)

摘要

Industrial-scale chromatographic fractionation and purification methods have been used increasingly in the last few years for plasma fractionation. This has resulted in the development of a new generation of therapeutic plasma derivatives, especially coagulation factors, protease inhibitors and anticoagulants. Implementation and combination of ion-exchange, affinity and size-exclusion chromatography have allowed the development of new therapeutic products with improved purity and safety for treating congenital or acquired plasma protein deficiencies in patients. More recently, the benefit of chromatographic purification of plasma proteins in the removal of plasma-borne viruses has been revealed. Development of packing materials with improved characteristics for industrial applications, including higher capacity and rigidity, should further promote the use of chromatography as an essential plasma fractionation tool and confine more and more the traditional ethanol precipitation methods to the final processing stages used to recover albumin.
原文英語
頁(從 - 到)3-15
頁數13
期刊Journal of Chromatography B: Biomedical Sciences and Applications
664
發行號1
DOIs
出版狀態已發佈 - 二月 3 1995
對外發佈Yes

指紋

Fractionation
Chromatography
Plasmas
Purification
Blood Proteins
Blood Coagulation Factors
Size exclusion chromatography
Protease Inhibitors
Viruses
Rigidity
Anticoagulants
Industrial applications
Albumins
Ion exchange
Ethanol
Derivatives
Processing

ASJC Scopus subject areas

  • Chemistry(all)

引用此文

Chromatography in plasma fractionation : benefits and future trends. / Burnouf, T.

於: Journal of Chromatography B: Biomedical Sciences and Applications, 卷 664, 編號 1, 03.02.1995, p. 3-15.

研究成果: 雜誌貢獻回顧型文獻

@article{b51b15a2cdb5436986eb606ad7982c5e,
title = "Chromatography in plasma fractionation: benefits and future trends",
abstract = "Industrial-scale chromatographic fractionation and purification methods have been used increasingly in the last few years for plasma fractionation. This has resulted in the development of a new generation of therapeutic plasma derivatives, especially coagulation factors, protease inhibitors and anticoagulants. Implementation and combination of ion-exchange, affinity and size-exclusion chromatography have allowed the development of new therapeutic products with improved purity and safety for treating congenital or acquired plasma protein deficiencies in patients. More recently, the benefit of chromatographic purification of plasma proteins in the removal of plasma-borne viruses has been revealed. Development of packing materials with improved characteristics for industrial applications, including higher capacity and rigidity, should further promote the use of chromatography as an essential plasma fractionation tool and confine more and more the traditional ethanol precipitation methods to the final processing stages used to recover albumin.",
author = "T. Burnouf",
year = "1995",
month = "2",
day = "3",
doi = "10.1016/0378-4347(94)00532-A",
language = "English",
volume = "664",
pages = "3--15",
journal = "Journal of Chromatography B: Biomedical Sciences and Applications",
issn = "0378-4347",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Chromatography in plasma fractionation

T2 - benefits and future trends

AU - Burnouf, T.

PY - 1995/2/3

Y1 - 1995/2/3

N2 - Industrial-scale chromatographic fractionation and purification methods have been used increasingly in the last few years for plasma fractionation. This has resulted in the development of a new generation of therapeutic plasma derivatives, especially coagulation factors, protease inhibitors and anticoagulants. Implementation and combination of ion-exchange, affinity and size-exclusion chromatography have allowed the development of new therapeutic products with improved purity and safety for treating congenital or acquired plasma protein deficiencies in patients. More recently, the benefit of chromatographic purification of plasma proteins in the removal of plasma-borne viruses has been revealed. Development of packing materials with improved characteristics for industrial applications, including higher capacity and rigidity, should further promote the use of chromatography as an essential plasma fractionation tool and confine more and more the traditional ethanol precipitation methods to the final processing stages used to recover albumin.

AB - Industrial-scale chromatographic fractionation and purification methods have been used increasingly in the last few years for plasma fractionation. This has resulted in the development of a new generation of therapeutic plasma derivatives, especially coagulation factors, protease inhibitors and anticoagulants. Implementation and combination of ion-exchange, affinity and size-exclusion chromatography have allowed the development of new therapeutic products with improved purity and safety for treating congenital or acquired plasma protein deficiencies in patients. More recently, the benefit of chromatographic purification of plasma proteins in the removal of plasma-borne viruses has been revealed. Development of packing materials with improved characteristics for industrial applications, including higher capacity and rigidity, should further promote the use of chromatography as an essential plasma fractionation tool and confine more and more the traditional ethanol precipitation methods to the final processing stages used to recover albumin.

UR - http://www.scopus.com/inward/record.url?scp=0028802159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028802159&partnerID=8YFLogxK

U2 - 10.1016/0378-4347(94)00532-A

DO - 10.1016/0378-4347(94)00532-A

M3 - Review article

C2 - 7757237

AN - SCOPUS:0028802159

VL - 664

SP - 3

EP - 15

JO - Journal of Chromatography B: Biomedical Sciences and Applications

JF - Journal of Chromatography B: Biomedical Sciences and Applications

SN - 0378-4347

IS - 1

ER -