摘要
Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 437-441 |
| 頁數 | 5 |
| 期刊 | Child's Nervous System |
| 卷 | 7 |
| 發行號 | 8 |
| DOIs | |
| 出版狀態 | 已發佈 - 十二月 1 1991 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology
引用此文
Choroid plexus tumors in childhood - Histopathologic study and clinico-pathological correlation. / Ho, Donald M.; Wong, Tai-Tong; Liu, Hung Chang.
於: Child's Nervous System, 卷 7, 編號 8, 01.12.1991, p. 437-441.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Choroid plexus tumors in childhood - Histopathologic study and clinico-pathological correlation
AU - Ho, Donald M.
AU - Wong, Tai-Tong
AU - Liu, Hung Chang
PY - 1991/12/1
Y1 - 1991/12/1
N2 - Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
AB - Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
KW - Childhood
KW - Choroid plexus tumor
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=0026348887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026348887&partnerID=8YFLogxK
U2 - 10.1007/BF00263185
DO - 10.1007/BF00263185
M3 - Article
C2 - 1790527
AN - SCOPUS:0026348887
VL - 7
SP - 437
EP - 441
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 8
ER -