Cholecystokinin acts through catecholaminergic mechanisms in the hypothalamus to influence ingestive behaviour in the rat

S. H. Tsai, E. Passaro, M. T. Lin

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

Administration of cholecystokinin (CCK)(0.2-0.6 μg in a volume of 2 μl) into the lateral cerebral ventricle caused a decrease in intake of food but a relative increase in intake of water (or water-to-food ratio) in rats. To determine whether the anorexic actions of CCK were mediated through the hypothalamic nuclei, rats were infused with CCK (0.02-0.12 μg in a volume of 0.5 μl) through previously implanted hypothalamic cannulae. Administration of CCK into the lateral hypothalamus, but not the anterior hypothalamus or ventromedial hypothalamus, caused decreased intake of food and a relative increased intake of water. In addition, the responses induced by injection of CCK into the hypothalamus were completely abolished by selective depletion of catecholamines in the hypothalamus (eg. noradrenaline and dopamine) with intra-hypothalamic injection of 6-hydroxydopamine. Intraperitoneal administration of 0.12 μg of CCK had no effect on the intake of food and water in rats. The data indicate that CCK acts through catecholaminergic mechanisms in the hypothalamus to influence feeding behaviour.

原文英語
頁(從 - 到)1351-1356
頁數6
期刊Neuropharmacology
23
發行號11
DOIs
出版狀態已發佈 - 1984
對外發佈Yes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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