CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

Shih Wei Wang, Shiow Lin Pan, Chieh Yu Peng, Der Yi Huang, An Chi Tsai, Ya Ling Chang, Jih Hwa Guh, Sheng Chu Kuo, Kuo Hsiung Lee, Che Ming Teng

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.
原文英語
頁(從 - 到)87-96
頁數10
期刊Cancer Letters
257
發行號1
DOIs
出版狀態已發佈 - 十一月 8 2007
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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