Chitosan Microspheres: Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug

Fwu Long Mi, Tsung Bi Wong, Shin Shing Shyu, Shon Foun Chang

研究成果: 雜誌貢獻文章同行評審

60 引文 斯高帕斯(Scopus)

摘要

Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.

原文英語
頁(從 - 到)747-759
頁數13
期刊Journal of Applied Polymer Science
71
發行號5
出版狀態已發佈 - 一月 31 1999
對外發佈

ASJC Scopus subject areas

  • 聚合物和塑料

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