Chitosan Microspheres: Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug

Fwu Long Mi, Tsung Bi Wong, Shin Shing Shyu, Shon Foun Chang

研究成果: 雜誌貢獻文章

60 引文 (Scopus)

摘要

Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.

原文英語
頁(從 - 到)747-759
頁數13
期刊Journal of Applied Polymer Science
71
發行號5
出版狀態已發佈 - 一月 31 1999
對外發佈Yes

指紋

Chitosan
Antibiotics
Microspheres
Physical properties
Anti-Bacterial Agents
Pharmaceutical Preparations
Microencapsulation
Spray drying
Liquids
Chemical properties
Swelling
Polymers
Adsorption
X rays
Scanning electron microscopy

ASJC Scopus subject areas

  • Polymers and Plastics

引用此文

Chitosan Microspheres : Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug. / Mi, Fwu Long; Wong, Tsung Bi; Shyu, Shin Shing; Chang, Shon Foun.

於: Journal of Applied Polymer Science, 卷 71, 編號 5, 31.01.1999, p. 747-759.

研究成果: 雜誌貢獻文章

@article{a09a45dbc57f458ba9ce8105973dca63,
title = "Chitosan Microspheres: Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug",
abstract = "Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.",
author = "Mi, {Fwu Long} and Wong, {Tsung Bi} and Shyu, {Shin Shing} and Chang, {Shon Foun}",
year = "1999",
month = "1",
day = "31",
language = "English",
volume = "71",
pages = "747--759",
journal = "Journal of Applied Polymer Science",
issn = "0021-8995",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Chitosan Microspheres

T2 - Modification of Polymeric Chem-Physical Properties of Spray-Dried Microspheres to Control the Release of Antibiotic Drug

AU - Mi, Fwu Long

AU - Wong, Tsung Bi

AU - Shyu, Shin Shing

AU - Chang, Shon Foun

PY - 1999/1/31

Y1 - 1999/1/31

N2 - Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.

AB - Antibiotic drug releasing from chitosan and acylchitosan microspheres was studied. The acylchitosan microspheres were prepared by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process for the improvement of chem-physical properties of polymer in controlling the release of antibiotic drug. A higher yield of microspheres was recovered by this improved process. Crystallinity, swelling ability, and the morphology of various microspheres were investigated by X-ray, water adsorption, and scanning electron microscopy studies. Results show that by modifying the microencapsulation process from spray-drying to spray in-liquid coagulating process, the chemical properties of the microsphere were varied from a hydrophilic chitosan microsphere to a hydrophobic acylchitosan microsphere, while the physical structure of the microsphere was varied from a porous chitosan microsphere to a dense acylchitosan microsphere. For the reasons, drug release rate of acylchitosan microspheres prepared by the novel spray microencapsulation method were apparently depressed, and the long-acting release of antibiotic drug was possible to be achieved.

UR - http://www.scopus.com/inward/record.url?scp=0032737783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032737783&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032737783

VL - 71

SP - 747

EP - 759

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

SN - 0021-8995

IS - 5

ER -