Chitosan: Its applications in drug-eluting devices

Mei Chin Chen, Fwu-Long Mi, Zi Xian Liao, Hsing Wen Sung

研究成果: 書貢獻/報告類型章節

25 引文 斯高帕斯(Scopus)

摘要

Chitosan, a naturally occurring polysaccharide derived from chitin, has been widely applied in drug delivery, tissue regeneration, wound healing, blood coagulation, and immunostimulation due to its well-known biocompatibility and biodegradability. Additionally, because of its unique cationic nature and the gel/film/matrix-forming capabilities, chitosan has been considered as a promising material for the development of medical devices. The current concept for developing medical devices often comprises the functionality of controlled release of bioactive agents such as drugs, proteins, or growth factors in order to fulfill their clinical applications. However, in biological fluids, the hydrophilic chitosan matrices may swell and deform dramatically through hydration, thus resulting in a rapid loss of the encapsulated drugs from the delivery device. Considerable efforts have therefore been made in chemically modifying chitosan to improve its physical properties and functionality. This review article focuses on the versatile modifications of chitosan matrices (ionic or chemical crosslinking) and the most recent research activities in drug-eluting devices, including vascular stents, artificial skin, bone grafts, and nerve guidance conduits.
原文英語
主出版物標題Advances in Polymer Science
頁面185-230
頁數46
243
版本1
DOIs
出版狀態已發佈 - 2011
對外發佈

出版系列

名字Advances in Polymer Science
號碼1
243
ISSN(列印)00653195

ASJC Scopus subject areas

  • 有機化學
  • 聚合物和塑料
  • 化學工程 (全部)

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