Chitosan hydrogel as an immunoisolative barrier for xenogeneic islet transplantation

Kai-Chiang Yang, Zhi Qi, Feng Huei Lin, Chang Chin Wu, Shoichiro Sumi

研究成果: 書貢獻/報告類型會議貢獻

摘要

Chitosan hydrogel was utilized as an immunoisolative barrier to facilitate the xenogeneic islets transplantation without immunosuppression. Rat islets were encapsulated in chitosan hydrogel and transplanted into the renal subcapsular space of diabetic mice. Non-fasting blood glucose level (NFBG), and body weight were recorded perioperatively. Mice were sacrificed at predetermined intervals and kidney transplanted with islets/chitosan hydrogel was retrieved for histologic examination. Results showed that the NFBG of mice transplanted with islets/chitosan hydrogel maintained in the range of 148-242 mg/dl for four weeks with increased body weight. Histologic sections revealed that the islets successfully engrafted at renal subcapsular space with positive insulin staining. This study indicates that the chitosan hydrogel protects encapsulated islets successfully during xenotransplantation.
原文英語
主出版物標題IFMBE Proceedings
頁面179-181
頁數3
27
DOIs
出版狀態已發佈 - 2010
對外發佈
事件3rd International Conference on the Development of Biomedical Engineering in Vietnam - Ho Chi Minh City, 越南
持續時間: 一月 11 2010一月 14 2010

其他

其他3rd International Conference on the Development of Biomedical Engineering in Vietnam
國家/地區越南
城市Ho Chi Minh City
期間1/11/101/14/10

ASJC Scopus subject areas

  • 生物醫學工程
  • 生物工程

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