Chitosan-based hydrogels prepared by UV polymerization for wound dressing

Han Yun Yao, Hong Ru Lin, Geng Pin Sue, Yiu Jiuan Lin

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.

原文英語
頁(從 - 到)155-167
頁數13
期刊Polymers and Polymer Composites
27
發行號3
DOIs
出版狀態已發佈 - 三月 1 2019

ASJC Scopus subject areas

  • 陶瓷和複合材料
  • 聚合物和塑料
  • 材料化學

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