TY - JOUR
T1 - Chinese medicines and bioactive compounds for treatment of stroke
AU - Jayakumar, Thanasekaran
AU - Elizebeth, Antoinet Ramola
AU - Yen, Ting lin
AU - Sheu, Joen rong
N1 - Publisher Copyright:
© 2014, Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2014/2
Y1 - 2014/2
N2 - Stroke is an important cause of mortality and morbidity worldwide but effective therapeutic strategy for the prevention of brain injury in patients with cerebral ischemia is lacking. Although tissue plasminogen activator has been used to treat stroke patients, this therapeutic strategy is confronted with ill side effects and is limited to patients within 3 h of a stroke. Due to the complexity of the events and the disappointing results from single agent trials, the combination of thrombolytic therapy and effective neural protection therapy may be an alternative strategy for patients with cerebral ischemia. Chinese medicine (CM) is the most widely practiced form of herbalism worldwide, as it is a sophisticated system of medical theory and practice that is specifically different from Western medicine. Most traditional therapeutic formulations consist of a combination of several drugs. The combination of multiple drugs is thought to maximize therapeutic efficacy by facilitating synergistic actions and preventing possible adverse effects while at the same time marking at multiple targets. CM has been labeled in ancient medicine systems as a treatment for various diseases associated with stroke. This review summarizes various CMs, bioactive compounds and their effects on cerebral ischemia.
AB - Stroke is an important cause of mortality and morbidity worldwide but effective therapeutic strategy for the prevention of brain injury in patients with cerebral ischemia is lacking. Although tissue plasminogen activator has been used to treat stroke patients, this therapeutic strategy is confronted with ill side effects and is limited to patients within 3 h of a stroke. Due to the complexity of the events and the disappointing results from single agent trials, the combination of thrombolytic therapy and effective neural protection therapy may be an alternative strategy for patients with cerebral ischemia. Chinese medicine (CM) is the most widely practiced form of herbalism worldwide, as it is a sophisticated system of medical theory and practice that is specifically different from Western medicine. Most traditional therapeutic formulations consist of a combination of several drugs. The combination of multiple drugs is thought to maximize therapeutic efficacy by facilitating synergistic actions and preventing possible adverse effects while at the same time marking at multiple targets. CM has been labeled in ancient medicine systems as a treatment for various diseases associated with stroke. This review summarizes various CMs, bioactive compounds and their effects on cerebral ischemia.
KW - Chinese medicine
KW - Taohong Siwu Decoction
KW - Xuefu Zhuyu Decoction
KW - andrographolide
KW - stroke
KW - xanthohumol
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U2 - 10.1007/s11655-014-1782-2
DO - 10.1007/s11655-014-1782-2
M3 - Article
C2 - 25012632
AN - SCOPUS:84939898037
SN - 1672-0415
VL - 21
SP - 90
EP - 101
JO - Chinese Journal of Integrative Medicine
JF - Chinese Journal of Integrative Medicine
IS - 2
ER -