Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis

Chi Tai Yeh, Gow Chin Yen

研究成果: 雜誌貢獻文章

28 引文 (Scopus)

摘要

Epidemiological and dietary studies have revealed an association between high intake of cruciferous vegetables and decreased cancer risk cancer. Sulforaphane, a phytochemical constituent of cruciferous vegetables, has received much attention as a potential cancer chemopreventive compound. Recent advances in the cellular and molecular biology of cancer have shed light on components of intracellular signaling cascades that can be molecular targets of chemoprevention by various anti-cancer agents. Metallothionein (MT), a primary antioxidant enzyme involved in the metabolism and detoxification of heavy metal, has been recognized as a molecular target for chemoprevention by natural anti-cancer agents, but the cellular signaling mechanisms that associate MT gene regulation are not yet clearly understood. Recent studies suggest that Nrf2-mediated signaling, which controls the expression of many of genes responsible for carcinogen detoxification and protection against oxidative stress, is regulated by sulforaphane. This contribution focuses on Nrf2-mediated signaling pathways, particularly in relation to MT gene induction and the apoptosis-inducing effects of sulforaphane.
原文英語
頁(從 - 到)23-32
頁數10
期刊Journal of Functional Foods
1
發行號1
DOIs
出版狀態已發佈 - 一月 2009
對外發佈Yes

指紋

metallothionein
apoptosis
Antioxidants
Apoptosis
antioxidants
chemoprevention
neoplasms
Metallothionein
antineoplastic agents
Enzymes
enzymes
Neoplasms
Chemoprevention
Vegetables
cell communication
gene induction
vegetable consumption
diet study techniques
carcinogens
cell biology

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

引用此文

Chemopreventive functions of sulforaphane : A potent inducer of antioxidant enzymes and apoptosis. / Yeh, Chi Tai; Yen, Gow Chin.

於: Journal of Functional Foods, 卷 1, 編號 1, 01.2009, p. 23-32.

研究成果: 雜誌貢獻文章

@article{6bd07782e68f4bc18910b134614b2bb0,
title = "Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis",
abstract = "Epidemiological and dietary studies have revealed an association between high intake of cruciferous vegetables and decreased cancer risk cancer. Sulforaphane, a phytochemical constituent of cruciferous vegetables, has received much attention as a potential cancer chemopreventive compound. Recent advances in the cellular and molecular biology of cancer have shed light on components of intracellular signaling cascades that can be molecular targets of chemoprevention by various anti-cancer agents. Metallothionein (MT), a primary antioxidant enzyme involved in the metabolism and detoxification of heavy metal, has been recognized as a molecular target for chemoprevention by natural anti-cancer agents, but the cellular signaling mechanisms that associate MT gene regulation are not yet clearly understood. Recent studies suggest that Nrf2-mediated signaling, which controls the expression of many of genes responsible for carcinogen detoxification and protection against oxidative stress, is regulated by sulforaphane. This contribution focuses on Nrf2-mediated signaling pathways, particularly in relation to MT gene induction and the apoptosis-inducing effects of sulforaphane.",
keywords = "Apoptosis, Chemopreventive agent, Metallothionein, Signaling pathway, Sulforaphane",
author = "Yeh, {Chi Tai} and Yen, {Gow Chin}",
year = "2009",
month = "1",
doi = "10.1016/j.jff.2008.09.002",
language = "English",
volume = "1",
pages = "23--32",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",
number = "1",

}

TY - JOUR

T1 - Chemopreventive functions of sulforaphane

T2 - A potent inducer of antioxidant enzymes and apoptosis

AU - Yeh, Chi Tai

AU - Yen, Gow Chin

PY - 2009/1

Y1 - 2009/1

N2 - Epidemiological and dietary studies have revealed an association between high intake of cruciferous vegetables and decreased cancer risk cancer. Sulforaphane, a phytochemical constituent of cruciferous vegetables, has received much attention as a potential cancer chemopreventive compound. Recent advances in the cellular and molecular biology of cancer have shed light on components of intracellular signaling cascades that can be molecular targets of chemoprevention by various anti-cancer agents. Metallothionein (MT), a primary antioxidant enzyme involved in the metabolism and detoxification of heavy metal, has been recognized as a molecular target for chemoprevention by natural anti-cancer agents, but the cellular signaling mechanisms that associate MT gene regulation are not yet clearly understood. Recent studies suggest that Nrf2-mediated signaling, which controls the expression of many of genes responsible for carcinogen detoxification and protection against oxidative stress, is regulated by sulforaphane. This contribution focuses on Nrf2-mediated signaling pathways, particularly in relation to MT gene induction and the apoptosis-inducing effects of sulforaphane.

AB - Epidemiological and dietary studies have revealed an association between high intake of cruciferous vegetables and decreased cancer risk cancer. Sulforaphane, a phytochemical constituent of cruciferous vegetables, has received much attention as a potential cancer chemopreventive compound. Recent advances in the cellular and molecular biology of cancer have shed light on components of intracellular signaling cascades that can be molecular targets of chemoprevention by various anti-cancer agents. Metallothionein (MT), a primary antioxidant enzyme involved in the metabolism and detoxification of heavy metal, has been recognized as a molecular target for chemoprevention by natural anti-cancer agents, but the cellular signaling mechanisms that associate MT gene regulation are not yet clearly understood. Recent studies suggest that Nrf2-mediated signaling, which controls the expression of many of genes responsible for carcinogen detoxification and protection against oxidative stress, is regulated by sulforaphane. This contribution focuses on Nrf2-mediated signaling pathways, particularly in relation to MT gene induction and the apoptosis-inducing effects of sulforaphane.

KW - Apoptosis

KW - Chemopreventive agent

KW - Metallothionein

KW - Signaling pathway

KW - Sulforaphane

UR - http://www.scopus.com/inward/record.url?scp=67651155826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651155826&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2008.09.002

DO - 10.1016/j.jff.2008.09.002

M3 - Article

AN - SCOPUS:67651155826

VL - 1

SP - 23

EP - 32

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

IS - 1

ER -