Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis

Chi Tai Yeh, Gow Chin Yen

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)


Epidemiological and dietary studies have revealed an association between high intake of cruciferous vegetables and decreased cancer risk cancer. Sulforaphane, a phytochemical constituent of cruciferous vegetables, has received much attention as a potential cancer chemopreventive compound. Recent advances in the cellular and molecular biology of cancer have shed light on components of intracellular signaling cascades that can be molecular targets of chemoprevention by various anti-cancer agents. Metallothionein (MT), a primary antioxidant enzyme involved in the metabolism and detoxification of heavy metal, has been recognized as a molecular target for chemoprevention by natural anti-cancer agents, but the cellular signaling mechanisms that associate MT gene regulation are not yet clearly understood. Recent studies suggest that Nrf2-mediated signaling, which controls the expression of many of genes responsible for carcinogen detoxification and protection against oxidative stress, is regulated by sulforaphane. This contribution focuses on Nrf2-mediated signaling pathways, particularly in relation to MT gene induction and the apoptosis-inducing effects of sulforaphane.
頁(從 - 到)23-32
期刊Journal of Functional Foods
出版狀態已發佈 - 1月 2009

ASJC Scopus subject areas

  • 食品科學
  • 醫藥(雜項)
  • 營養與營養學


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