Chemistry and health effects of furanocoumarins in grapefruit

Wei Lun Hung, Joon Hyuk Suh, Yu Wang

研究成果: 雜誌貢獻回顧型文獻

31 引文 (Scopus)

摘要

Furanocoumarins are a specific group of secondary metabolites that commonly present in higher plants, such as citrus plants. The major furanocoumarins found in grapefruits (Citrus paradisi) include bergamottin, epoxybergamottin, and 6′,7′-dihydroxybergamottin. During biosynthesis of these furanocoumarins, coumarins undergo biochemical modifications corresponding to a prenylation reaction catalyzed by the cytochrome P450 enzymes with the subsequent formation of furan rings. Because of undesirable interactions with several medications, many studies have developed methods for grapefruit furanocoumarin quantification that include high-performance liquid chromatography coupled with UV detector or mass spectrometry. The distribution of furanocoumarins in grapefruits is affected by several environmental conditions, such as processing techniques, storage temperature, and packing materials. In the past few years, grapefruit furanocoumarins have been demonstrated to exhibit several biological activities including antioxidative, -inflammatory, and -cancer activities as well as bone health promotion both in vitro and in vivo. Notably, furanocoumarins potently exerted antiproliferative activities against cancer cell growth through modulation of several molecular pathways, such as regulation of the signal transducer and activator of transcription 3, nuclear factor-κB, phosphatidylinositol-3-kinase/AKT, and mitogen-activated protein kinase expression. Therefore, based on this review, we suggest furanocoumarins may serve as bioactive components that contribute, at least in part, to the health benefits of grapefruit.
原文英語
頁(從 - 到)71-83
頁數13
期刊Journal of Food and Drug Analysis
25
發行號1
DOIs
出版狀態已發佈 - 一月 1 2017
對外發佈Yes

指紋

Citrus paradisi
psoralens
grapefruits
chemistry
Health
Cytochrome P-450 Enzyme System
Phosphatidylinositol 3-Kinase
Prenylation
Coumarins
STAT3 Transcription Factor
health promotion
coumarins
Furocoumarins
Citrus
furans
transducers (equipment)
phosphatidylinositol 3-kinase
Insurance Benefits
Mitogen-Activated Protein Kinases
Health Promotion

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

引用此文

Chemistry and health effects of furanocoumarins in grapefruit. / Hung, Wei Lun; Suh, Joon Hyuk; Wang, Yu.

於: Journal of Food and Drug Analysis, 卷 25, 編號 1, 01.01.2017, p. 71-83.

研究成果: 雜誌貢獻回顧型文獻

Hung, Wei Lun ; Suh, Joon Hyuk ; Wang, Yu. / Chemistry and health effects of furanocoumarins in grapefruit. 於: Journal of Food and Drug Analysis. 2017 ; 卷 25, 編號 1. 頁 71-83.
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