Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chia Nan Chen, Che Jen Hsiao, Shoei Sheng Lee, Jih Hwa Guh, Po Cheng Chiang, Chih Chiang Huang, Wei Jan Huang

研究成果: 雜誌貢獻文章同行評審

24 引文 斯高帕斯(Scopus)


Our previous studies demonstrated that eight prenylated flavanones (1-8), isolated from Taiwanese propolis, were capable of a broad spectrum of biological activities. Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. It therefore seemed interesting to improve their activity via a semi-synthetic strategy. In this study, 12 novel prenylated flavanones were synthesised in our laboratory and their activities were assessed for two human prostate cancer cell lines, PC-3 and DU-145, and a human hepatoma cell line, Hep-3B. Of these compounds, 10c, 11 and 12 showed more potent cytotoxicity against the PC-3 cell line than 5-Fu. Using cytometric analysis followed by double staining with annexin V-FITC and propidium iodide, it was observed that these compounds induced apoptosis as well. This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development.
頁(從 - 到)116-124
期刊Natural Product Research
出版狀態已發佈 - 1月 1 2012

ASJC Scopus subject areas

  • 植物科學
  • 生物化學
  • 分析化學
  • 有機化學


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