Chemical Constituents of the Endophytic Fungus Phomopsis asparagi Isolated from the Plant Peperomia sui

Hsun Shuo Chang, Chien Jou Peng, Ming Jen Cheng, Ho Cheng Wu, Hing Yuen Chan, Sung Yuan Hsieh, Gwo Fang Yuan, Ih Sheng Chen

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Investigation of the ethyl acetate-soluble layer from the liquid fermentation of Phomopsis asparagi, an endophytic fungus isolated from the Taiwanese endemic plant of Peperomia sui T.T. Lin & S.Y. Lu, led to the isolation of a new cytochalasin, phomocytochalasin A (1), and one benzenoid, phomoaspardiol (2), which was isolated from nature for the first time, along with eight known compounds including two cytochalasins, four benzenoids, one chromone, and one steroid. The structures of the isolates were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques, as well as by comparison with literature reports. Among the isolates, cytochalasin J showed androgen receptor (AR) antagonism with the IC50 value of 6.20 μM.
原文英語
頁(從 - 到)504-508
頁數5
期刊Chemistry of Natural Compounds
54
發行號3
DOIs
出版狀態已發佈 - 5月 1 2018
對外發佈

ASJC Scopus subject areas

  • 植物科學

指紋

深入研究「Chemical Constituents of the Endophytic Fungus Phomopsis asparagi Isolated from the Plant Peperomia sui」主題。共同形成了獨特的指紋。

引用此