Chemical constituents from the fungus antrodia cinnamomea

Ming Der Wu, Ming Jen Cheng, Yen Lin Chen, Hsun-Hsuo-Chang, Yueh Hsiung Kuo, Chih Chuan Lin, Ho Cheng Wu

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.
原文英語
頁(從 - 到)129-130
頁數2
期刊Natural Product Communications
14
發行號1
DOIs
出版狀態已發佈 - 1月 2019
對外發佈

ASJC Scopus subject areas

  • 藥理
  • 藥物發現
  • 植物科學
  • 補充和替代醫學

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