Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623

Ting Yu Cho, Guei Jane Wang, Yu Ming Ju, Mei Chuan Chen, Tzong Huei Lee

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Three previously unreported benzofurans, namely acumifurans A-C (1-3), along with five known compounds, 2-(isopropyl-1′-ol)-2,3-dihydrobenzofuran-5-carbinol (4), fomannoxin alcohol (5), fomannoxin (6), acremine S (7) and cyclo(L-Pro-L-Leu) (8), were isolated from the ethyl acetate extracts of the fermented broths of termite n est associated Xylaria acuminatilongissima YMJ623. Compound 4, a synthe tic benzofuran analogue of 1-3, was isolated for the first time from natural resources. The str uctures of 1-8 were determined through spectroscopic data analyses. The absolute configurations of 1-4 were established based mainly on ROESY experiment and Mosher's reaction, and compared the optical rotation data with the literatures. The effects of these compounds on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were also evaluated. Of the compounds tested, 6 showed a mild NO production inhibitory activity without any cytotoxicity, and its mean maximum inhibition (Emax) at 100μM was 42.98±0.87 %. Eight compounds including three new benzofurans 1-3 were isolated from the ethyl acetate extracts of the fermented broth of termite-associated Xylaria acuminatilongissima YMJ623. The absolute configurations of 1-4 were established based on optical rotational data, ROESY experiments and Mosher's reaction. Benzofuran analogue 6 showed mild NO production inhibitory activity on LPS-induced RAW264.7 cells.
原文英語
頁(從 - 到)404-409
頁數6
期刊Journal of the Chinese Chemical Society
63
發行號5
DOIs
出版狀態已發佈 - 五月 1 2016

ASJC Scopus subject areas

  • Chemistry(all)

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