CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

Kuo Hua Tung, Cheng Wei Lin, Chun Chen Kuo, Li Tzu Li, Ya Hsun Kuo, Chung Wu Lin, Han Chung Wu

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

Pancreatic adenocarcinoma is an aggressive disease with a high mortality rate. In this study, we have newly generated a monoclonal antibody (mAb), Pa65-2, which specifically binds to pancreatic cancer cells and tumor blood vessels. The target protein of Pa65-2 is identified as human clathrin heavy chain (CHC). In vitro and In vivo study showed that suppression of CHC either by shRNA or by Pa65-2 inhibited tumor growth and angiogenesis. One of the key functions of CHC was to bind with the hypoxia-inducing factor (HIF)-1α protein, increasing the stability of this protein and facilitating its nuclear translocation, thereby regulating the expression of VEGF. Taken together, our findings indicate that CHC plays a role in the processes of tumorigenesis and angiogenesis. Pa65-2 antibody or CHC shRNA can potentially be used for pancreatic cancer therapy.

原文英語
頁(從 - 到)58-67
頁數10
期刊Cancer Letters
331
發行號1
DOIs
出版狀態已發佈 - 四月 30 2013
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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