Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution

Shiou Hwei Yeh, Hurng Yi Wang, Ching Yi Tsai, Chuan Liang Kao, Jyh Yuan Yang, Hwan Wun Liu, Ih Jen Su, Shih Feng Tsai, Ding Shinn Chen, Pei Jer Chen, Yuan Teh Lee, Che Ming Teng, Pan Chyr Yang, Hong Nerng Ho, Ming Fu Chang, Jin Town Wang, Shan Chwen Chang, Chuan Liang Kao, Wei Kung Wang, Cheng Hsiang HsiaoPo Ren Hsueh

研究成果: 雜誌貢獻文章同行評審

107 引文 斯高帕斯(Scopus)


Since early March 2003, the severe acute respiratory syndrome (SARS) coronavirus (CoV) infection has claimed 346 cases and 37 deaths in Taiwan. The epidemic occurred in two stages. The first stage caused limited familial or hospital infections and lasted from early March to mid-April. All cases had clear contact histories, primarily from Guangdong or Hong Kong. The second stage resulted in a large outbreak in a municipal hospital, and quickly spread to northern and southern Taiwan from late April to mid-June. During this stage, there were some sporadic cases with untraceable contact histories. To investigate the origin and transmission route of SARS-CoV in Taiwan's epidemic, we conducted a systematic viral lineage study by sequencing the entire viral genome from ten SARS patients. SARS-CoV viruses isolated from Taiwan were found closely related to those from Guangdong and Hong Kong. In addition, all cases from the second stage belonged to the same lineage after the municipal hospital outbreak, including the patients without an apparent contact history. Analyses of these full-length sequences showed a positive selection occurring during SARS-CoV virus evolution. The mismatch distribution indicated that SARS viral genomes did not reach equilibrium and suggested a recent introduction of the viruses into human populations. The estimated genome mutation rate was ≈0.1 per genome, demonstrating possibly one of the lowest rates among known RNA viruses.
頁(從 - 到)2542-2547
期刊Proceedings of the National Academy of Sciences of the United States of America
出版狀態已發佈 - 2月 22 2004

ASJC Scopus subject areas

  • 多學科


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