Characterization of Musclin as a new target for treatment of hypertension

Jia Wei Lin, Cheng Chia Tsai, Li Jen Chen, Ho Shan Niu, Chen Kuei Chang, Chiang Shan Niu

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Musclin is a novel skeletal muscle-derived factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Recently, it has been demonstrated that musclin is involved in the pathogenesis of spontaneously hypertensive rats (SHRs). However, it is known as a genetic hypertension model. In the present study, we aim to investigate the role of musclin in another animal model of hypertension and characterize the direct effect of musclin on vascular contraction. The results show that expression of musclin was increased in arterial tissues isolated from DOCA-salt induced hypertensive rats or the normal rats received repeated vasoconstriction with phenylephrine. Additionally, direct incubation with phenylephrine did not modify the expression of musclin in the in vitro studies. Also, the direct effect of musclin on the increase of intracellular calcium was observed in a concentration-dependent manner. These results provide the evidence to support that musclin is involved in hypertension. Thus, musclin is suitable to be considered as a novel target for treatment of hypertension.
原文英語
文章編號354348
期刊BioMed Research International
2014
DOIs
出版狀態已發佈 - 2014

指紋

Rats
Phenylephrine
Hypertension
Muscle
Desoxycorticosterone Acetate
Skeletal Muscle
Protein Sorting Signals
Genetic Models
Animals
Inbred SHR Rats
Complementary DNA
Salts
Vasoconstriction
Tissue
Calcium
Blood Vessels
Animal Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

引用此文

Characterization of Musclin as a new target for treatment of hypertension. / Lin, Jia Wei; Tsai, Cheng Chia; Chen, Li Jen; Niu, Ho Shan; Chang, Chen Kuei; Niu, Chiang Shan.

於: BioMed Research International, 卷 2014, 354348, 2014.

研究成果: 雜誌貢獻文章

Lin, Jia Wei ; Tsai, Cheng Chia ; Chen, Li Jen ; Niu, Ho Shan ; Chang, Chen Kuei ; Niu, Chiang Shan. / Characterization of Musclin as a new target for treatment of hypertension. 於: BioMed Research International. 2014 ; 卷 2014.
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