Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Fuu Jen Tsai, Tsung Jung Ho, Chi Fung Cheng, Yi Tzone Shiao, Wen Kuei Chien, Jin Hua Chen, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Cheng Wen Lin, Jaung Geng Lin, Yu Ching Lan, Yu Huei Liu, Chien Hui Hung, Jung Chun Lin, Chih Chien Lin, Chih Ho LaiWen Miin Liang, Ying Ju Lin

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3ß and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.
原文英語
頁(從 - 到)15470-15489
頁數20
期刊Oncotarget
8
發行號9
DOIs
出版狀態已發佈 - 2017

ASJC Scopus subject areas

  • Oncology

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    Tsai, F. J., Ho, T. J., Cheng, C. F., Shiao, Y. T., Chien, W. K., Chen, J. H., Liu, X., Tsang, H., Lin, T. H., Liao, C. C., Huang, S. M., Li, J. P., Lin, C. W., Lin, J. G., Lan, Y. C., Liu, Y. H., Hung, C. H., Lin, J. C., Lin, C. C., ... Lin, Y. J. (2017). Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. Oncotarget, 8(9), 15470-15489. https://doi.org/10.18632/oncotarget.14657