Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan

Te Mao Li, Yang Hao Yu, Fuu Jen Tsai, Chi Fung Cheng, Yang Chang Wu, Tsung Jung Ho, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Jung Chun Lin, Chih Chien Lin, Wen Miin Liang, Ying Ju Lin

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Ethnopharmacological relevance In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6% to 18%. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatoryanti-inflammatory activities in cancer cells. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan. Materials and methods We identified 6939 lung cancer patients (ICD-9-CM: 162). We allocated 264 CHM users and 528 CHM-non users, matched for age, gender, duration, and regular treatment. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by a longer follow up time and more cases of hyperlipidemia and liver cirrhosis. This group exhibited a lower mortality hazard ratio (0.48, 95% confidence interval [0.39–0.61], p < 0.001), after adjusting for comorbidities. The trend was also observed that the cumulative survival probability was higher in CHM than in non-CHM users (p < 0.0001, log rank test). Analysis of their CHM prescription pattern revealed that Bu-Zhong-Yi-Qi-Tang (BZYQT), Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), and Bai-He-Gu-Jin-Tang (BHGJT); and Bei-Mu (BM), Xing-Ren (XR) and Ge-Gen (GG) were found to be the top three formulas and herbs, respectively. Among them, BM was the core CHM of the major cluster, and Jie-Geng (JG) and Mai-Men-Dong-Tang (MMDT) were important CHMs by CHM network analysis. Conclusion The use of CHM as an adjunctive therapy may reduce the mortality hazard ratio of lung cancer patients. The investigation of their comprehensive CHM prescription patterns might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments for lung cancer patients.

原文英語
頁(從 - 到)92-100
頁數9
期刊Journal of Ethnopharmacology
213
DOIs
出版狀態已發佈 - 三月 1 2018

指紋

Herbal Medicine
Taiwan
Lung Neoplasms
Survival
Prescriptions
Mortality
International Classification of Diseases
Chi-Square Distribution
Therapeutics
Hyperlipidemias
Liver Cirrhosis
Comorbidity
Neoplasms
Anti-Inflammatory Agents
Logistic Models

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

引用此文

Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. / Li, Te Mao; Yu, Yang Hao; Tsai, Fuu Jen; Cheng, Chi Fung; Wu, Yang Chang; Ho, Tsung Jung; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chiu Chu; Huang, Shao Mei; Li, Ju Pi; Lin, Jung Chun; Lin, Chih Chien; Liang, Wen Miin; Lin, Ying Ju.

於: Journal of Ethnopharmacology, 卷 213, 01.03.2018, p. 92-100.

研究成果: 雜誌貢獻文章

Li, TM, Yu, YH, Tsai, FJ, Cheng, CF, Wu, YC, Ho, TJ, Liu, X, Tsang, H, Lin, TH, Liao, CC, Huang, SM, Li, JP, Lin, JC, Lin, CC, Liang, WM & Lin, YJ 2018, 'Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan', Journal of Ethnopharmacology, 卷 213, 頁 92-100. https://doi.org/10.1016/j.jep.2017.10.031
Li, Te Mao ; Yu, Yang Hao ; Tsai, Fuu Jen ; Cheng, Chi Fung ; Wu, Yang Chang ; Ho, Tsung Jung ; Liu, Xiang ; Tsang, Hsinyi ; Lin, Ting Hsu ; Liao, Chiu Chu ; Huang, Shao Mei ; Li, Ju Pi ; Lin, Jung Chun ; Lin, Chih Chien ; Liang, Wen Miin ; Lin, Ying Ju. / Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. 於: Journal of Ethnopharmacology. 2018 ; 卷 213. 頁 92-100.
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title = "Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan",
abstract = "Ethnopharmacological relevance In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6{\%} to 18{\%}. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatoryanti-inflammatory activities in cancer cells. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan. Materials and methods We identified 6939 lung cancer patients (ICD-9-CM: 162). We allocated 264 CHM users and 528 CHM-non users, matched for age, gender, duration, and regular treatment. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by a longer follow up time and more cases of hyperlipidemia and liver cirrhosis. This group exhibited a lower mortality hazard ratio (0.48, 95{\%} confidence interval [0.39–0.61], p < 0.001), after adjusting for comorbidities. The trend was also observed that the cumulative survival probability was higher in CHM than in non-CHM users (p < 0.0001, log rank test). Analysis of their CHM prescription pattern revealed that Bu-Zhong-Yi-Qi-Tang (BZYQT), Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), and Bai-He-Gu-Jin-Tang (BHGJT); and Bei-Mu (BM), Xing-Ren (XR) and Ge-Gen (GG) were found to be the top three formulas and herbs, respectively. Among them, BM was the core CHM of the major cluster, and Jie-Geng (JG) and Mai-Men-Dong-Tang (MMDT) were important CHMs by CHM network analysis. Conclusion The use of CHM as an adjunctive therapy may reduce the mortality hazard ratio of lung cancer patients. The investigation of their comprehensive CHM prescription patterns might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments for lung cancer patients.",
keywords = "Chinese herbal medicine, Lung cancer, Survival",
author = "Li, {Te Mao} and Yu, {Yang Hao} and Tsai, {Fuu Jen} and Cheng, {Chi Fung} and Wu, {Yang Chang} and Ho, {Tsung Jung} and Xiang Liu and Hsinyi Tsang and Lin, {Ting Hsu} and Liao, {Chiu Chu} and Huang, {Shao Mei} and Li, {Ju Pi} and Lin, {Jung Chun} and Lin, {Chih Chien} and Liang, {Wen Miin} and Lin, {Ying Ju}",
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T1 - Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan

AU - Li, Te Mao

AU - Yu, Yang Hao

AU - Tsai, Fuu Jen

AU - Cheng, Chi Fung

AU - Wu, Yang Chang

AU - Ho, Tsung Jung

AU - Liu, Xiang

AU - Tsang, Hsinyi

AU - Lin, Ting Hsu

AU - Liao, Chiu Chu

AU - Huang, Shao Mei

AU - Li, Ju Pi

AU - Lin, Jung Chun

AU - Lin, Chih Chien

AU - Liang, Wen Miin

AU - Lin, Ying Ju

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Ethnopharmacological relevance In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6% to 18%. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatoryanti-inflammatory activities in cancer cells. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan. Materials and methods We identified 6939 lung cancer patients (ICD-9-CM: 162). We allocated 264 CHM users and 528 CHM-non users, matched for age, gender, duration, and regular treatment. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by a longer follow up time and more cases of hyperlipidemia and liver cirrhosis. This group exhibited a lower mortality hazard ratio (0.48, 95% confidence interval [0.39–0.61], p < 0.001), after adjusting for comorbidities. The trend was also observed that the cumulative survival probability was higher in CHM than in non-CHM users (p < 0.0001, log rank test). Analysis of their CHM prescription pattern revealed that Bu-Zhong-Yi-Qi-Tang (BZYQT), Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), and Bai-He-Gu-Jin-Tang (BHGJT); and Bei-Mu (BM), Xing-Ren (XR) and Ge-Gen (GG) were found to be the top three formulas and herbs, respectively. Among them, BM was the core CHM of the major cluster, and Jie-Geng (JG) and Mai-Men-Dong-Tang (MMDT) were important CHMs by CHM network analysis. Conclusion The use of CHM as an adjunctive therapy may reduce the mortality hazard ratio of lung cancer patients. The investigation of their comprehensive CHM prescription patterns might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments for lung cancer patients.

AB - Ethnopharmacological relevance In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6% to 18%. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatoryanti-inflammatory activities in cancer cells. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan. Materials and methods We identified 6939 lung cancer patients (ICD-9-CM: 162). We allocated 264 CHM users and 528 CHM-non users, matched for age, gender, duration, and regular treatment. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by a longer follow up time and more cases of hyperlipidemia and liver cirrhosis. This group exhibited a lower mortality hazard ratio (0.48, 95% confidence interval [0.39–0.61], p < 0.001), after adjusting for comorbidities. The trend was also observed that the cumulative survival probability was higher in CHM than in non-CHM users (p < 0.0001, log rank test). Analysis of their CHM prescription pattern revealed that Bu-Zhong-Yi-Qi-Tang (BZYQT), Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), and Bai-He-Gu-Jin-Tang (BHGJT); and Bei-Mu (BM), Xing-Ren (XR) and Ge-Gen (GG) were found to be the top three formulas and herbs, respectively. Among them, BM was the core CHM of the major cluster, and Jie-Geng (JG) and Mai-Men-Dong-Tang (MMDT) were important CHMs by CHM network analysis. Conclusion The use of CHM as an adjunctive therapy may reduce the mortality hazard ratio of lung cancer patients. The investigation of their comprehensive CHM prescription patterns might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments for lung cancer patients.

KW - Chinese herbal medicine

KW - Lung cancer

KW - Survival

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