Characteristics and outcomes in primary aldosteronism patients harboring glucocorticoid-remediable aldosteronism

TAIPAI Study Group

研究成果: 雜誌貢獻文章同行評審

摘要

The clinical characteristics and surgical prognosis of glucocorticoid-remediable aldosteronism (GRA, also known as familial hyperaldosteronism type 1, FH-I) have not been widely studied. Using data from the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry retrospectively, we describe the associated clinical factors for GRA and clinical predictors of surgical outcomes among identified GRA patients. We found 79 GRA-positive (51.2±13.8 years; women 39 (49.4%)) and 114 GRA-negative primary aldosteronism (PA) patients matched with age, gender, and body mass index. Lower plasma aldosterone concentrations (PACs) and aldosterone-renin ratios were found among GRA-positive individuals. Multivariable logistic regression demonstrated that a PAC≤40 ng/dL could predict concealed GRA individuals (OR 0.523, p=0.037). Low serum potassium (OR 0.285, p=0.008), but not the presence of GRA, was associated with hypertension-remission. Of note, PRA (OR 11.645, p=0.045) and hypokalemia (OR 0.133, p=0.048) were associated with hypertension-remission in GRA patients. Unilateral primary aldosteronism patients harboring concomitant GRA were not associated with inferior hypertension-remission after an adrenalectomy. Low serum potassium and high PRA were positively associated with hypertension-remission in GRA patients.
原文英語
文章編號1816
期刊Biomedicines
9
發行號12
DOIs
出版狀態已發佈 - 12月 2021

ASJC Scopus subject areas

  • 醫藥(雜項)
  • 生物化學、遺傳與分子生物學 (全部)

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