Chapter 8: Role of kynurenine pathway in allergy

Hirokazu Kawasaki, Shau Ku Huang

研究成果: 書貢獻/報告類型章節

摘要

Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

原文英語
主出版物標題Targeting the Broadly Pathogenic Kynurenine Pathway
發行者Springer International Publishing
頁面109-119
頁數11
ISBN(電子)9783319118703
ISBN(列印)9783319118697
DOIs
出版狀態已發佈 - 一月 1 2015
對外發佈Yes

指紋

Allergies
Kynurenine
Tryptophan
Hypersensitivity
Metabolites
Aryl Hydrocarbon Receptors
Chemical sensors
Immunotherapy
Allergens
Modulation
Degradation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

引用此文

Kawasaki, H., & Huang, S. K. (2015). Chapter 8: Role of kynurenine pathway in allergy. 於 Targeting the Broadly Pathogenic Kynurenine Pathway (頁 109-119). Springer International Publishing. https://doi.org/10.1007/978-3-319-11870-3_8

Chapter 8 : Role of kynurenine pathway in allergy. / Kawasaki, Hirokazu; Huang, Shau Ku.

Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. p. 109-119.

研究成果: 書貢獻/報告類型章節

Kawasaki, H & Huang, SK 2015, Chapter 8: Role of kynurenine pathway in allergy. 於 Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 頁 109-119. https://doi.org/10.1007/978-3-319-11870-3_8
Kawasaki H, Huang SK. Chapter 8: Role of kynurenine pathway in allergy. 於 Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing. 2015. p. 109-119 https://doi.org/10.1007/978-3-319-11870-3_8
Kawasaki, Hirokazu ; Huang, Shau Ku. / Chapter 8 : Role of kynurenine pathway in allergy. Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. 頁 109-119
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