摘要
| 原文 | 未定義 |
|---|---|
| 頁（從 - 到） | 197-202 |
| 頁數 | 6 |
| 期刊 | 核子醫學雜誌 |
| 卷 | 16 |
| 發行號 | 4 |
| DOIs | |
| 出版狀態 | 已發佈 - 2003 |
Keywords
- 甲狀腺激素
- 皮質醇
- 輻射曝露
引用此文
Changes of Serum Cortisol and Thyroid Hormones after Irradiation. / Huang, Wen-Sheng; 鄧文炳(Win-Ping Deng); Chen, Ching-Yuan; Fu, Ying-Kai; Yang, Ping-Cheng; Cheng, Cheng-Yi.
於: 核子醫學雜誌, 卷 16, 編號 4, 2003, p. 197-202.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Changes of Serum Cortisol and Thyroid Hormones after Irradiation
AU - Huang, Wen-Sheng
AU - 鄧, 文炳(Win-Ping Deng)
AU - Chen, Ching-Yuan
AU - Fu, Ying-Kai
AU - Yang, Ping-Cheng
AU - Cheng, Cheng-Yi
PY - 2003
Y1 - 2003
N2 - Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all ＜23 nmol/L, 49% mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P＜0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.
AB - Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all ＜23 nmol/L, 49% mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P＜0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.
KW - thyroid hormones
KW - cortisol
KW - irradiation
KW - 甲狀腺激素
KW - 皮質醇
KW - 輻射曝露
U2 - 10.6332/ANMS.1604.007
DO - 10.6332/ANMS.1604.007
M3 - 文章
VL - 16
SP - 197
EP - 202
JO - 核子醫學雜誌
JF - 核子醫學雜誌
SN - 1022-923X
IS - 4
ER -