Changes in the mechanisms of steroid action during aging

Chang Wen-Chang, George S. Roth

研究成果: 雜誌貢獻文章

24 引文 (Scopus)

摘要

This paper reviews some representative changes in steroid action and hormone receptors as a function of age. In many of the cases studied, receptor concentrations (but not affinity) were found to decrease during aging. These investigations employed various cells and tissues from humans and animals. Loss of receptors is closely correlated with decline in particular biological responses in a number of studies. Moreover, loss of glucocorticoid receptors seems to occur in individual cells (rather than by a simple loss of receptor containing cells from complex tissues) when denned post-mitotic cell populations have been investigated. Therefore, it appears that reductions in various steroid receptor concentrations in targets cells are closely, if not casually, related to decreased biological responsiveness during senescence. Possible mechanisms of steroid receptor change during aging are suggested and discussed.

原文英語
頁(從 - 到)889-892
頁數4
期刊Journal of Steroid Biochemistry
11
發行號1 PART 3
DOIs
出版狀態已發佈 - 1979
對外發佈Yes

指紋

Aging of materials
Steroid Receptors
Steroids
Tissue
Glucocorticoid Receptors
Animals
Cells
Hormones
Population

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

引用此文

Changes in the mechanisms of steroid action during aging. / Wen-Chang, Chang; Roth, George S.

於: Journal of Steroid Biochemistry, 卷 11, 編號 1 PART 3, 1979, p. 889-892.

研究成果: 雜誌貢獻文章

Wen-Chang, Chang ; Roth, George S. / Changes in the mechanisms of steroid action during aging. 於: Journal of Steroid Biochemistry. 1979 ; 卷 11, 編號 1 PART 3. 頁 889-892.
@article{ca866107decd4551a68a8f3da43b1f7c,
title = "Changes in the mechanisms of steroid action during aging",
abstract = "This paper reviews some representative changes in steroid action and hormone receptors as a function of age. In many of the cases studied, receptor concentrations (but not affinity) were found to decrease during aging. These investigations employed various cells and tissues from humans and animals. Loss of receptors is closely correlated with decline in particular biological responses in a number of studies. Moreover, loss of glucocorticoid receptors seems to occur in individual cells (rather than by a simple loss of receptor containing cells from complex tissues) when denned post-mitotic cell populations have been investigated. Therefore, it appears that reductions in various steroid receptor concentrations in targets cells are closely, if not casually, related to decreased biological responsiveness during senescence. Possible mechanisms of steroid receptor change during aging are suggested and discussed.",
author = "Chang Wen-Chang and Roth, {George S.}",
year = "1979",
doi = "10.1016/0022-4731(79)90025-6",
language = "English",
volume = "11",
pages = "889--892",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier Limited",
number = "1 PART 3",

}

TY - JOUR

T1 - Changes in the mechanisms of steroid action during aging

AU - Wen-Chang, Chang

AU - Roth, George S.

PY - 1979

Y1 - 1979

N2 - This paper reviews some representative changes in steroid action and hormone receptors as a function of age. In many of the cases studied, receptor concentrations (but not affinity) were found to decrease during aging. These investigations employed various cells and tissues from humans and animals. Loss of receptors is closely correlated with decline in particular biological responses in a number of studies. Moreover, loss of glucocorticoid receptors seems to occur in individual cells (rather than by a simple loss of receptor containing cells from complex tissues) when denned post-mitotic cell populations have been investigated. Therefore, it appears that reductions in various steroid receptor concentrations in targets cells are closely, if not casually, related to decreased biological responsiveness during senescence. Possible mechanisms of steroid receptor change during aging are suggested and discussed.

AB - This paper reviews some representative changes in steroid action and hormone receptors as a function of age. In many of the cases studied, receptor concentrations (but not affinity) were found to decrease during aging. These investigations employed various cells and tissues from humans and animals. Loss of receptors is closely correlated with decline in particular biological responses in a number of studies. Moreover, loss of glucocorticoid receptors seems to occur in individual cells (rather than by a simple loss of receptor containing cells from complex tissues) when denned post-mitotic cell populations have been investigated. Therefore, it appears that reductions in various steroid receptor concentrations in targets cells are closely, if not casually, related to decreased biological responsiveness during senescence. Possible mechanisms of steroid receptor change during aging are suggested and discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018647940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018647940&partnerID=8YFLogxK

U2 - 10.1016/0022-4731(79)90025-6

DO - 10.1016/0022-4731(79)90025-6

M3 - Article

C2 - 385994

AN - SCOPUS:0018647940

VL - 11

SP - 889

EP - 892

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

IS - 1 PART 3

ER -