Changes in the lymphocyte subset after double-filtration plasmapheresis

Jiann Horng Yeh, Pei Ju Chien, Yu-Mei Hsueh, Chwen-Ming Shih, Hou Chang Chiu

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

To investigate the direct impact of membrane plasmapheresis on the distribution of lymphocyte subsets, paired blood specimens from 18 healthy volunteers were studied before and immediately after a single session of double-filtration plasmapheresis (DFP). After a single session of DFP treatment, the number of helper T cells had increased by 2.34% (P = .0142), whereas the suppressor T cells decreased by 2.22% (P = .0095), with consequent increases in the T-helper/T-suppressor (Th/Ts) ratio (P < .0001). The number of B cells was also significantly increased (P = .0012) after DFP treatment; however, total T and natural killer cells did not differ after treatment. Older volunteers (>40 years) had significantly higher percentages of B (P = .0002) and helper T (P = .0432) cells after treatment. In contrast, younger subjects had a lower percentage of suppressor T cells (P = .0174). However, the Th/Ts ratio increased significantly irrespective of age group (P = .0016) and sex (P = .0016). A single session of membrane plasmapheresis seemed to activate the cellular immune system in our sample of 18 healthy volunteers, increasing the number of B cells and the Th/Ts ratio.
原文英語
頁(從 - 到)940-944
頁數5
期刊American Journal of Clinical Pathology
128
發行號6
DOIs
出版狀態已發佈 - 十二月 2007

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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