Changes in T-cell subsets after radiation therapy

S. Yang, S. Rafla, E. Youssef, H. Selim, N. Salloum, J. Y. Chuang

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18 引文 斯高帕斯(Scopus)

摘要

The T-cell subsets of 129 patients with cancer were counted before and after radiation therapy. The cells were labeled with monoclonal antibodies that were specific for each type of T cell. Significant changes after therapy were decreases in the proportion of T-helper/inducer cells, pan-T cells, and in the ratio of T-helper/inducer to T-suppressor/cytotoxic cells. There was an increase in the percentage of T-suppressor/cytotoxic cells. When the site of the primary cancer was considered, genitourinary cancer and cancer of the head and neck both showed a decreased percentage of T-helper/inducer cells and a reduced ratio of T-helper/inducer to T-suppressor/cytotoxic cells. The percentage of pan-T cells in head and neck cancer and the ratio of T-helper/inducer to T-suppressor/cytotoxic cells in breast cancer were decreased. The percentage of T-helper cells was particularly decreased by radiation therapy in advanced stages of cancer, in higher grade tumors, and in larger tumors. The absolute numbers of various T-cell subsets were decreased in all groups.
原文英語
頁(從 - 到)537-540
頁數4
期刊Radiology
168
發行號2
DOIs
出版狀態已發佈 - 一月 1 1988
對外發佈Yes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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