Changes in superoxide dismutase activity and mRNA in vivo after short- term supplementation with trilinolein in rats

Paul Chan, Wen Pin Huang, Ju Chi Liu, Yi Jen Chen, Juei Tang Cheng

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Background: Oxidative damage plays a central role in atherogenesis and antioxidation defense mechanisms may prevent atherosclerosis. This study evaluated the effect of short-term supplementation of the natural lipophilic antioxidant trilinolein on superoxide dismutase (SOD) activity and SOD-mRNA gene expression in vivo in rat vital organs. Methods: Male Wistar rats (n = 8) were injected intraperitoneally with trilinolein (1 mM/ml/kg/day in 0.5% ethanol) daily for three consecutive days. Two control groups (n = 8) were administered saline or 0.5% ethanol in saline, respectively, for three days. Results: Assay of SOD activity and SOD-mRNA by Northern blotting in rat liver, spleen and brain showed significant increases in SOD activity and increased SOD-mRNA gene expression. Conclusions: The natural lipophilic antioxidant trilinolein potentiates the SOD antioxidation defense mechanism and increases gene expression of SOD-mRNA after short-term supplementation in rats.
原文英語
頁(從 - 到)355-360
頁數6
期刊Chinese Medical Journal (Taipei)
63
發行號5
出版狀態已發佈 - 五月 2000

ASJC Scopus subject areas

  • Medicine(all)

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