Changes in fatigue in rectal cancer patients before and after therapy: a systematic review and meta-analysis

Chang Wen-Pei, Jen Hsiu-Ju

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Purpose: Fatigue is a common problem among rectal cancer patients and can affect their quality of life. This study conducted a systematic review to better understand changes in fatigue severity in rectal cancer patients before, during, and after they undergo therapy. Methods: We used preset keywords to search the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, and ProQuest databases for relevant studies published between 2000 and 2018, and data analysis was performed using Comprehensive Meta-Analysis (CMA) software (version 2.2.048) and SPSS software (version 19.0). In total, nine articles with complete data were included in our meta-analysis. Results: Fatigue conditions were compared before the start of therapy (baseline) and at 1 month (time 1), 3 months (time 2), 6 months (time 3), and 12 months (time 4) after the start of therapy. The standardized mean differences (SMDs) of the pooling effects size were 1.013 (95% confidence interval (CI) 0.217–1.810), − 0.551 (95% CI − 0.647 to − 0.456), − 0.330 (95% CI − 0.427 to − 0.233), and − 0.149 (95% CI − 0.221 to − 0.078), respectively. Subsequent analysis with a linear mixed effect model revealed that the estimate of the time variable was − 0.226 (p = 0.047), which indicates that the severity of fatigue varies over time and over the course of treatment. The results reveal that fatigue affects rectal cancer patients even before they start therapy. Conclusion: Although fatigue worsened during the first month after cancer therapy, it gradually improved thereafter.

原文英語
頁(從 - 到)2513-2522
頁數10
期刊Supportive Care in Cancer
28
發行號6
DOIs
出版狀態已發佈 - 六月 1 2020

ASJC Scopus subject areas

  • 腫瘤科

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