Ceramide in apoptotic signaling and anticancer therapy

C. F. Lin, Chia-Ling Chen, Yee-Shin Lin

研究成果: 雜誌貢獻文章同行評審

66 引文 斯高帕斯(Scopus)

摘要

Ceramide, a product of sphingolipid metabolism, is generated in response to various stress stimuli, such as tumor necrosis factor-α, CD95 /Fas, chemotherapeutic agents, and irradiation. Ceramide may modulate the biochemical and cellular processes that lead to apoptosis. However, the mechanisms by which ceramide regulates apoptotic events are not fully defined. It is believed that the biological effect of ceramide depends on its concentration, the activation or differentiation status of the cell, and the time frame of action. Here, we discuss the metabolism and cell apoptotic signaling of ceramide. The involvement of protein kinases (i.e. P13K/Akt and GSK-3β) and protein phosphatases (i.e. PP1 and PP2A), Bcl-2 family proteins, mitochondrial damage, and caspase cascade activation are demonstrated. Further, ceramide and its derivatives have recently been incorporated into strategies for anticancer therapies. An understanding of the apoptotic signaling pathways mediated by ceramide may shed light on its potential for therapeutic intervention.
原文英語
頁(從 - 到)1609-1616
頁數8
期刊Current Medicinal Chemistry
13
發行號14
DOIs
出版狀態已發佈 - 六月 2006

ASJC Scopus subject areas

  • 有機化學
  • 生物化學、遺傳與分子生物學 (全部)
  • 生物化學
  • 藥理

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