Cell-mediated immune response to human immunodeficiency virus (hiv) type 1 in seronegative homosexual men with recent sexual exposure to hiv-1

Mario Clerici, Janis V. Giorgi, Chen Cheng Chou, Vaheideh K. Gudeman, Jerome A. Zack, Phalguni Gupta, Hong Nerng Ho, Parunag G. Nishanian, Jay A. Berzofsky, Gene M. Shearer

研究成果: 雜誌貢獻文章同行評審

342 引文 斯高帕斯(Scopus)

摘要

Although human immunodeficiency virus (HIV) type 1 infection is efficiently transmitted by sexual intercourse, some individuals whose sexual behavior places them at extremely high risk for infection have nevertheless remained HIV-1-seronegative. An investigation was undertaken to determine whether such individuals have circulating T helper cells that are sensitized to HIV- 1. Five very high risk men who had recent sexual exposure to HIV-1 were studied. Peripheral blood mononuclear cells from all 5 produced interleukin (IL)-2 in culture in response to synthetic amphipathic HIV-1 envelope peptides. One of the 5 high-risk men has subsequently serocon- verted, while 4 have remained seronegative. All were initially culture-negative, and those who have remained seronegative were also virus-negative by polymerase chain reaction (PCR) testing 10 months after they were first studied. These results demonstrate that a cell-mediated immune response to HIV-1 can be detected in the absence of a humoral immune response in individuals recently exposed to HIV-1. Furthermore, IL-2 production by T cells in response to synthetic peptides may be a more sensitive test for exposure to HIV-1 than antibody, lymphoproliferation, or PCR tests.
原文英語
頁(從 - 到)1012-1019
頁數8
期刊Journal of Infectious Diseases
165
發行號6
DOIs
出版狀態已發佈 - 1月 1 1992
對外發佈

ASJC Scopus subject areas

  • 傳染性疾病
  • 免疫學和過敏
  • 公共衛生、環境和職業健康
  • 免疫學

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